UPB1

Entrez Summary: This gene encodes a protein that belongs to the CN hydrolase family. Beta-ureidopropionase catalyzes the last step in the pyrimidine degradation pathway. The pyrimidine bases uracil and thymine are degraded via the consecutive action of dihydropyrimidine dehydrogenase (DHPDH), dihydropyrimidinase (DHP) and beta-ureidopropionase (UP) to beta-alanine and beta-aminoisobutyric acid, respectively. UP deficiencies are associated with N-carbamyl-beta-amino aciduria and may lead to abnormalities in neurological activity. [provided by RefSeq, Jul 2008].
UniProt Summary: Converts N-carbamoyl-beta-aminoisobutyrate and N- carbamoyl-beta-alanine (3-ureidopropanoate) to, respectively, beta-aminoisobutyrate and beta-alanine, ammonia and carbon dioxide.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

beta-alanine biosynthetic process via 3-ureidopropionate
beta-ureidopropionase activity
beta-alanine biosynthetic process
beta-alanine metabolic process
pyrimidine nucleoside catabolic process
nucleoside catabolic process
pyrimidine nucleoside metabolic process
neurotransmitter biosynthetic process
pyrimidine-containing compound catabolic process
glycosyl compound catabolic process
nucleobase-containing small molecule catabolic process
cellular amino acid biosynthetic process
neurotransmitter metabolic process
protein homotetramerization
pyrimidine-containing compound metabolic process
nucleoside metabolic process
glycosyl compound metabolic process
protein tetramerization
carbohydrate derivative catabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
cellular amino acid metabolic process
protein homooligomerization
regulation of neurotransmitter levels
nucleobase-containing compound catabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
small molecule catabolic process
aromatic compound catabolic process
organic cyclic compound catabolic process
protein complex oligomerization
nucleobase-containing small molecule metabolic process
small molecule biosynthetic process
zinc ion binding
protein homodimerization activity
carboxylic acid metabolic process
oxoacid metabolic process
organic acid metabolic process
carbohydrate derivative metabolic process
organonitrogen compound catabolic process