UPP1

Gene Information

Official Symbol: UPP1
Official Name: uridine phosphorylase 1
Aliases and Previous Symbols: N/A
Entrez ID: 7378
UniProt: Q16831
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a uridine phosphorylase, an enzyme that catalyzes the reversible phosphorylation of uridine (or 2'- deoxyuridine) to uracil and ribose-1-phosphate (or deoxyribose-1-phosphate). The encoded enzyme functions in the degradation and salvage of pyrimidine ribonucleosides. [provided by RefSeq, Oct 2016].
UniProt Summary: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate (PubMed:7488099). The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. {ECO:0000269|PubMed:7488099, ECO:0000305}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17343
Expression level (log2 read counts): 1.78

Expression Distribution

Screen	Score
Nocodazole 0.2μM R02 exp64	1.9
Nocodazole 0.1μM R03 exp94	1.99
SB743921 0.001μM R05 exp244	2.23
DABN racemic mixture R03 exp93	2.75

uridine catabolic process
uridine phosphorylase activity
uridine metabolic process
pyrimidine nucleotide salvage
pyrimidine ribonucleotide salvage
UMP salvage
UMP metabolic process
pyrimidine ribonucleoside monophosphate metabolic process
UMP biosynthetic process
pyrimidine ribonucleoside monophosphate biosynthetic process
pyrimidine-containing compound salvage
pyrimidine nucleoside salvage
pyrimidine ribonucleoside catabolic process
nucleotide salvage
pyrimidine ribonucleoside metabolic process
pyrimidine nucleoside biosynthetic process
pyrimidine nucleoside monophosphate biosynthetic process
nucleoside salvage
pyrimidine nucleoside monophosphate metabolic process
pyrimidine ribonucleotide biosynthetic process
pyrimidine nucleoside catabolic process
ribonucleoside catabolic process
pyrimidine ribonucleotide metabolic process
ribonucleoside monophosphate biosynthetic process
cellular metabolic compound salvage
nucleoside catabolic process
pyrimidine nucleoside metabolic process
nucleoside biosynthetic process
cellular response to glucose starvation
glycosyl compound biosynthetic process
pyrimidine-containing compound catabolic process
nucleoside monophosphate biosynthetic process
glycosyl compound catabolic process
pyrimidine nucleotide biosynthetic process
ribonucleoside monophosphate metabolic process
nucleobase-containing small molecule catabolic process
pyrimidine-containing compound biosynthetic process
pyrimidine nucleotide metabolic process
nucleotide catabolic process
nucleoside phosphate catabolic process