UQCC2 [The Human Chemical-Genetic Interaction Map Project]

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======= UQCC2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UQCC2
  * **<color #00a2e8>Official Name</color>**: ubiquinol-cytochrome c reductase complex assembly factor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84300|84300]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BRT2|Q9BRT2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UQCC2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UQCC2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614461|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a nucleoid protein localized to the mitochondria inner membrane. The encoded protein affects regulation of insulin secretion, mitochondrial ATP production, and myogenesis through modulation of mitochondrial respiratory chain activity. [provided by RefSeq, Oct 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex). Plays a role in the modulation of respiratory chain activities such as oxygen consumption and ATP production and via its modulation of the respiratory chain activity can regulate skeletal muscle differentiation and insulin secretion by pancreatic beta-cells. Involved in cytochrome b translation and/or stability. {ECO:0000269|PubMed:22363741, ECO:0000269|PubMed:24385928}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|respiratory chain complex III assembly|
|mitochondrial respiratory chain complex III assembly|
|positive regulation of mitochondrial translation|
|regulation of skeletal muscle cell differentiation|
|regulation of mitochondrial translation|
|regulation of mitochondrial gene expression|
|regulation of oxidative phosphorylation|
|cytochrome complex assembly|
|mitochondrial nucleoid|
|regulation of skeletal muscle tissue development|
|mitochondrial intermembrane space|
|mitochondrial respiratory chain complex assembly|
|regulation of ATP metabolic process|
|positive regulation of translation|
|regulation of striated muscle tissue development|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|positive regulation of cellular protein catabolic process|
|positive regulation of cellular amide metabolic process|
|regulation of generation of precursor metabolites and energy|
|regulation of insulin secretion|
|regulation of peptide hormone secretion|
|positive regulation of protein catabolic process|
|regulation of cellular protein catabolic process|
|regulation of hormone secretion|
|nuclear body|
|regulation of translation|
|positive regulation of cellular catabolic process|
|mitochondrial matrix|
|regulation of protein catabolic process|
|mitochondrial inner membrane|
|regulation of cellular amide metabolic process|
|positive regulation of catabolic process|
|mitochondrion organization|
|regulation of protein secretion|
|regulation of peptide secretion|
|posttranscriptional regulation of gene expression|
|regulation of hormone levels|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|regulation of cellular catabolic process|
|cellular protein-containing complex assembly|
|regulation of catabolic process|
|regulation of protein localization|
|mitochondrion|
|protein-containing complex assembly|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|positive regulation of protein metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|protein-containing complex subunit organization|
|regulation of transport|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-2.63|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|-2.45|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-1.7|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|1.71|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|1.84|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|1.93|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.98|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.01|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.04|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.13|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|2.14|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.27|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|3.15|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|4.4|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrpl21|MRPL21]]|0.515|
|[[:human genes:u:uqcc1|UQCC1]]|0.49|
|[[:human genes:b:bcs1l|BCS1L]]|0.487|
|[[:human genes:r:rpusd4|RPUSD4]]|0.478|
|[[:human genes:m:mrpl53|MRPL53]]|0.473|
|[[:human genes:c:coq6|COQ6]]|0.467|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.465|
|[[:human genes:v:vars2|VARS2]]|0.46|
|[[:human genes:c:coq3|COQ3]]|0.46|
|[[:human genes:f:fastkd5|FASTKD5]]|0.458|
|[[:human genes:t:tomm20|TOMM20]]|0.458|
|[[:human genes:m:mtpap|MTPAP]]|0.451|
|[[:human genes:m:mrpl23|MRPL23]]|0.449|
|[[:human genes:m:mrps34|MRPS34]]|0.449|
|[[:human genes:p:pgm3|PGM3]]|0.445|
|[[:human genes:u:uqcrq|UQCRQ]]|0.443|
|[[:human genes:s:selrc1|SELRC1]]|0.443|
|[[:human genes:y:yars2|YARS2]]|0.441|
|[[:human genes:d:dap3|DAP3]]|0.438|
|[[:human genes:m:mrps12|MRPS12]]|0.437|
|[[:human genes:g:gfm2|GFM2]]|0.436|
|[[:human genes:p:pnpt1|PNPT1]]|0.433|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.43|
|[[:human genes:t:tars2|TARS2]]|0.43|
|[[:human genes:m:mrps21|MRPS21]]|0.429|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.429|
|[[:human genes:c:c17orf89|C17orf89]]|0.428|
|[[:human genes:m:mrps16|MRPS16]]|0.426|
|[[:human genes:m:mrps5|MRPS5]]|0.422|
|[[:human genes:g:gfm1|GFM1]]|0.42|
|[[:human genes:t:tmem242|TMEM242]]|0.419|
|[[:human genes:c:coq2|COQ2]]|0.418|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.417|
|[[:human genes:g:gatc|GATC]]|0.417|
|[[:human genes:a:aars2|AARS2]]|0.414|
|[[:human genes:s:sco2|SCO2]]|0.413|
|[[:human genes:d:dnlz|DNLZ]]|0.413|
|[[:human genes:c:chchd4|CHCHD4]]|0.412|
|[[:human genes:p:pars2|PARS2]]|0.409|
|[[:human genes:m:mtg1|MTG1]]|0.408|
|[[:human genes:m:mrpl15|MRPL15]]|0.406|
|[[:human genes:m:mrps6|MRPS6]]|0.405|
|[[:human genes:h:hars2|HARS2]]|0.405|
|[[:human genes:m:mrps14|MRPS14]]|0.404|
|[[:human genes:c:coq5|COQ5]]|0.404|
|[[:human genes:m:mrps11|MRPS11]]|0.402|
|[[:human genes:p:pdss1|PDSS1]]|0.4|
|[[:human genes:r:rars2|RARS2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3257
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UQCC2 Expression in NALM6 Cells: 5.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>