UQCC2

Gene Information

Official Symbol: UQCC2
Official Name: ubiquinol-cytochrome c reductase complex assembly factor 2
Aliases and Previous Symbols: N/A
Entrez ID: 84300
UniProt: Q9BRT2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a nucleoid protein localized to the mitochondria inner membrane. The encoded protein affects regulation of insulin secretion, mitochondrial ATP production, and myogenesis through modulation of mitochondrial respiratory chain activity. [provided by RefSeq, Oct 2012].
UniProt Summary: Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex). Plays a role in the modulation of respiratory chain activities such as oxygen consumption and ATP production and via its modulation of the respiratory chain activity can regulate skeletal muscle differentiation and insulin secretion by pancreatic beta-cells. Involved in cytochrome b translation and/or stability. {ECO:0000269|PubMed:22363741, ECO:0000269|PubMed:24385928}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CVT-10216 0.1μM R06 exp278	-2.63
HMS-I2 5μM R06 exp287	-2.45
UM0011500 5μM R05 exp245	-1.7
Ribavirin 10 to 15μM on day4 R04 exp160	1.71
Ribavirin 10μM R01 exp52	1.84
Phenformin 20μM R03 exp143	1.93
PU-H71 1μM R08 exp515	1.98
GSK-J4 1.5μM R08 exp441	2.01
Deferoxamine 11μM R07 exp350	2.04
Mubritinib 0.2μM R01 exp48	2.13
Bisphenol S 100μM R08 exp458	2.14
Fluvastatin 2.2μM R06 exp282	2.27
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	3.15
Ammonium tetrathiomolybdate 10μM R08 exp448	4.4

Gene	Correlation
MRPL21	0.515
UQCC1	0.49
BCS1L	0.487
RPUSD4	0.478
MRPL53	0.473
COQ6	0.467
HSD17B10	0.465
VARS2	0.46
COQ3	0.46
FASTKD5	0.458
TOMM20	0.458
MTPAP	0.451
MRPL23	0.449
MRPS34	0.449
PGM3	0.445
UQCRQ	0.443
SELRC1	0.443
YARS2	0.441
DAP3	0.438
MRPS12	0.437
GFM2	0.436
PNPT1	0.433
RNASEH1	0.43
TARS2	0.43
MRPS21	0.429
GTPBP10	0.429
C17orf89	0.428
MRPS16	0.426
MRPS5	0.422
GFM1	0.42
TMEM242	0.419
COQ2	0.418
SUPV3L1	0.417
GATC	0.417
AARS2	0.414
SCO2	0.413
DNLZ	0.413
CHCHD4	0.412
PARS2	0.409
MTG1	0.408
MRPL15	0.406
MRPS6	0.405
HARS2	0.405
MRPS14	0.404
COQ5	0.404
MRPS11	0.402
PDSS1	0.4
RARS2	0.4

Global Fraction of Cell Lines Where Essential: 6/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3257
Expression level (log2 read counts): 5.09

Expression Distribution

respiratory chain complex III assembly
mitochondrial respiratory chain complex III assembly
positive regulation of mitochondrial translation
regulation of skeletal muscle cell differentiation
regulation of mitochondrial translation
regulation of mitochondrial gene expression
regulation of oxidative phosphorylation
cytochrome complex assembly
mitochondrial nucleoid
regulation of skeletal muscle tissue development
mitochondrial intermembrane space
mitochondrial respiratory chain complex assembly
regulation of ATP metabolic process
positive regulation of translation
regulation of striated muscle tissue development
regulation of muscle tissue development
regulation of muscle organ development
positive regulation of cellular protein catabolic process
positive regulation of cellular amide metabolic process
regulation of generation of precursor metabolites and energy
regulation of insulin secretion
regulation of peptide hormone secretion
positive regulation of protein catabolic process
regulation of cellular protein catabolic process
regulation of hormone secretion
nuclear body
regulation of translation
positive regulation of cellular catabolic process
mitochondrial matrix
regulation of protein catabolic process
mitochondrial inner membrane
regulation of cellular amide metabolic process
positive regulation of catabolic process
mitochondrion organization
regulation of protein secretion
regulation of peptide secretion
posttranscriptional regulation of gene expression
regulation of hormone levels
regulation of protein transport
regulation of peptide transport