UQCC1

Entrez Summary: This gene encodes a transmembrane protein that is structurally similar to the mouse basic fibroblast growth factor repressed ZIC-binding protein. In mouse this protein may be involved in fibroblast growth factor regulated growth control. In humans, polymorphisms in this gene are associated with variation in human height and osteoarthritis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Phenformin 20μM R05 exp212	1.76
UM0125461 0.74μM R02 exp84	1.8
BI-D1870 2μM R04 exp162	1.83
Azithromycin 100μM R08 exp452	1.91
Chloroquine 32μM R08 exp470	1.99
Ribavirin 10 to 15μM on day4 R04 exp160	2.18
Phenformin 20μM R03 exp143	2.35
Ammonium tetrathiomolybdate 10μM R08 exp448	3.68

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

mitochondrial respiratory chain complex III assembly
respiratory chain complex III assembly
positive regulation of mitochondrial translation
regulation of mitochondrial translation
regulation of mitochondrial gene expression
cytochrome complex assembly
mitochondrial respiratory chain complex assembly
positive regulation of translation
positive regulation of cellular amide metabolic process
cytoplasmic vesicle
regulation of translation
mitochondrial inner membrane
regulation of cellular amide metabolic process
mitochondrion organization
posttranscriptional regulation of gene expression
cellular protein-containing complex assembly
protein-containing complex assembly
positive regulation of cellular protein metabolic process
positive regulation of protein metabolic process
protein-containing complex subunit organization
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process