TBRG4

Entrez Summary: N/A
UniProt Summary: Plays a role in processing of mitochondrial RNA precursors and in stabilization of a subset of mature mitochondrial RNA species, such as MT-CO1, MT-CO2, MT-CYB, MT-CO3, MT-ND3, MT-ND5 and MT-ATP8/6. May play a role in cell cycle progression (PubMed:9383053). {ECO:0000269|PubMed:28335001, ECO:0000269|PubMed:9383053}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
HMS-I2 10μM R06 exp288	-2.72
Hypoxia 5%O2 R04 exp191	-2.6
HMS-I2 5μM R06 exp287	-1.82
Hydroxychloroquine 30μM R08 exp490	1.86
SB743921 0.001μM R05 exp244	1.89
Nocodazole 0.1μM R03 exp94	1.96
Etoposide 0.3μM R05 exp199	1.99
Phenformin 20μM R05 exp212	1.99
Phenformin 20μM R03 exp143	2
GSK626616 14μM R08 exp485	2.01
Citral 50μM R06 exp274	2.17
UM0131023 0.05μM R05 exp248	2.45
IWR1 50μM R08 exp495	2.47
NN-Diethyl-meta-toluamide 500μM R08 exp438	2.64
DABN racemic mixture R03 exp93	2.69
CB-839 10μM R05 exp224	3.01
R-DABN 8μM R03 exp111	3.02

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

mitochondrial mRNA processing
regulation of mitochondrial mRNA stability
mitochondrial RNA processing
mitochondrial RNA metabolic process
mitochondrial gene expression
cell cycle arrest
cellular respiration
regulation of mRNA stability
regulation of RNA stability
regulation of mRNA catabolic process
energy derivation by oxidation of organic compounds
protein kinase activity
regulation of mRNA metabolic process
mitochondrial matrix
generation of precursor metabolites and energy
mRNA processing
posttranscriptional regulation of gene expression
negative regulation of cell cycle
mRNA metabolic process
regulation of cellular catabolic process
RNA processing
positive regulation of cell population proliferation
oxidation-reduction process
protein phosphorylation
regulation of catabolic process
cell cycle process
regulation of cell cycle
mitochondrion
phosphorylation
cell cycle
RNA binding
regulation of cell population proliferation
RNA metabolic process
gene expression