URAD

Official Symbol: URAD
Official Name: ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase
Aliases and Previous Symbols: N/A
Entrez ID: 646625
UniProt: A6NGE7
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: N/A
UniProt Summary: Catalyzes the stereoselective decarboxylation of 2-oxo- 4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin. {ECO:0000305}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
SGC0946 7μM R03 exp151	-1.97
ABT-702 5μM R07 exp318	-1.81

allantoin biosynthetic process
urate catabolic process
allantoin metabolic process
carboxy-lyase activity
urate metabolic process
purine nucleobase metabolic process
nucleobase metabolic process
purine-containing compound catabolic process
peroxisome
purine-containing compound metabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
small molecule catabolic process
aromatic compound catabolic process
cellular component
organic cyclic compound catabolic process
drug metabolic process
amide biosynthetic process
nucleobase-containing small molecule metabolic process
cellular amide metabolic process
organic acid metabolic process
organonitrogen compound catabolic process
heterocycle biosynthetic process
organic cyclic compound biosynthetic process
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process
small molecule metabolic process
organic substance catabolic process
cellular catabolic process