USE1 [The Human Chemical-Genetic Interaction Map Project]

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======= USE1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: USE1
  * **<color #00a2e8>Official Name</color>**: unconventional SNARE in the ER 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55850|55850]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NZ43|Q9NZ43]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=USE1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20USE1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610675|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. {ECO:0000269|PubMed:15272311}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Use1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|lysosomal transport|
|vacuolar transport|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|lysosome|
|Golgi vesicle transport|
|protein catabolic process|
|endoplasmic reticulum membrane|
|secretion by cell|
|endoplasmic reticulum|
|export from cell|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|secretion|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|organic substance catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|-2.33|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-1.92|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.75|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-1.7|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 10/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|2/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2832
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='USE1 Expression in NALM6 Cells: 4.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>