USF1 [The Human Chemical-Genetic Interaction Map Project]

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======= USF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: USF1
  * **<color #00a2e8>Official Name</color>**: upstream transcription factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7391|7391]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P22415|P22415]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=USF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20USF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/191523|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been defined on chromosome 21. [provided by RefSeq, Feb 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HLH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of transcription from RNA polymerase II promoter by glucose|
|positive regulation of transcription from RNA polymerase II promoter by glucose|
|carbon catabolite regulation of transcription from RNA polymerase II promoter|
|carbon catabolite activation of transcription from RNA polymerase II promoter|
|positive regulation of transcription by glucose|
|late viral transcription|
|carbon catabolite activation of transcription|
|regulation of transcription by glucose|
|carbon catabolite regulation of transcription|
|negative regulation of fibrinolysis|
|regulation of fibrinolysis|
|bHLH transcription factor binding|
|positive regulation of hemostasis|
|positive regulation of blood coagulation|
|positive regulation of coagulation|
|positive regulation of wound healing|
|positive regulation of response to wounding|
|cellular response to nutrient|
|regulation of blood coagulation|
|regulation of hemostasis|
|regulation of coagulation|
|double-stranded DNA binding|
|histone deacetylase binding|
|glucose metabolic process|
|viral transcription|
|viral gene expression|
|lipid homeostasis|
|regulation of wound healing|
|response to UV|
|hexose metabolic process|
|cellular response to insulin stimulus|
|regulation of response to wounding|
|glucose homeostasis|
|carbohydrate homeostasis|
|monosaccharide metabolic process|
|transcription factor complex|
|response to nutrient|
|response to insulin|
|cellular response to nutrient levels|
|nuclear chromatin|
|cellular response to extracellular stimulus|
|protein-containing complex binding|
|cellular response to peptide hormone stimulus|
|response to light stimulus|
|cellular response to peptide|
|cellular response to external stimulus|
|response to hypoxia|
|enzyme binding|
|response to decreased oxygen levels|
|response to oxygen levels|
|response to peptide hormone|
|sequence-specific DNA binding|
|response to radiation|
|protein kinase binding|
|response to peptide|
|carbohydrate metabolic process|
|transcription by RNA polymerase II|
|protein heterodimerization activity|
|regulation of body fluid levels|
|response to nutrient levels|
|response to extracellular stimulus|
|cellular response to organonitrogen compound|
|positive regulation of response to external stimulus|
|cellular response to hormone stimulus|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|cellular response to nitrogen compound|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|protein homodimerization activity|
|response to hormone|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|identical protein binding|
|response to nitrogen compound|
|regulation of response to external stimulus|
|nucleobase-containing compound biosynthetic process|
|chemical homeostasis|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|organic cyclic compound biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.56|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-2.26|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-2.05|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|-2|
|[[:results:exp224|CB-839 10μM R05 exp224]]|-1.78|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.424|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17893
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='USF1 Expression in NALM6 Cells: 6.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>