USF1

Entrez Summary: This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been defined on chromosome 21. [provided by RefSeq, Feb 2013].
UniProt Summary: Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of transcription from RNA polymerase II promoter by glucose
positive regulation of transcription from RNA polymerase II promoter by glucose
carbon catabolite regulation of transcription from RNA polymerase II promoter
carbon catabolite activation of transcription from RNA polymerase II promoter
positive regulation of transcription by glucose
late viral transcription
carbon catabolite activation of transcription
regulation of transcription by glucose
carbon catabolite regulation of transcription
negative regulation of fibrinolysis
regulation of fibrinolysis
bHLH transcription factor binding
positive regulation of hemostasis
positive regulation of blood coagulation
positive regulation of coagulation
positive regulation of wound healing
positive regulation of response to wounding
cellular response to nutrient
regulation of blood coagulation
regulation of hemostasis
regulation of coagulation
double-stranded DNA binding
histone deacetylase binding
glucose metabolic process
viral transcription
viral gene expression
lipid homeostasis
regulation of wound healing
response to UV
hexose metabolic process
cellular response to insulin stimulus
regulation of response to wounding
glucose homeostasis
carbohydrate homeostasis
monosaccharide metabolic process
transcription factor complex
response to nutrient
response to insulin
cellular response to nutrient levels
nuclear chromatin