USP13

Gene Information

Official Symbol: USP13
Official Name: ubiquitin specific peptidase 13
Aliases and Previous Symbols: N/A
Entrez ID: 8975
UniProt: Q92995
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum- associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34- containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Also regulates ERAD through the deubiquitination of UBL4A a component of the BAG6/BAT3 complex. Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro; however, additional experiments are required to confirm such data. {ECO:0000269|PubMed:17653289, ECO:0000269|PubMed:21571647, ECO:0000269|PubMed:21659512, ECO:0000269|PubMed:21811243, ECO:0000269|PubMed:21962518, ECO:0000269|PubMed:22216260, ECO:0000269|PubMed:24424410}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10476
Expression level (log2 read counts): 6.7

Expression Distribution

Screen	Score
GSK461364A 0.005μM R03 exp125	1.76
UM0129480 7μM R02 exp85	2.27

zf-UBP
UCH
UBA

maintenance of unfolded protein involved in ERAD pathway
protein K6-linked deubiquitination
maintenance of unfolded protein
BAT3 complex binding
protein K29-linked deubiquitination
positive regulation of ERAD pathway
Lys48-specific deubiquitinase activity
proteasome binding
melanocyte differentiation
ubiquitin-like protein ligase binding
regulation of ERAD pathway
protein K63-linked deubiquitination
pigment cell differentiation
protein K48-linked deubiquitination
positive regulation of response to endoplasmic reticulum stress
developmental pigmentation
thiol-dependent ubiquitinyl hydrolase activity
ubiquitin binding
regulation of response to endoplasmic reticulum stress
ERAD pathway
cysteine-type endopeptidase activity
pigmentation
chaperone binding
positive regulation of proteasomal protein catabolic process
thiol-dependent ubiquitin-specific protease activity
positive regulation of proteolysis involved in cellular protein catabolic process
positive regulation of cellular protein catabolic process
protein stabilization
regulation of proteasomal protein catabolic process
regulation of proteolysis involved in cellular protein catabolic process
positive regulation of protein catabolic process
regulation of cellular protein catabolic process
response to endoplasmic reticulum stress
process utilizing autophagic mechanism
autophagy
protein deubiquitination
regulation of protein stability
ubiquitin protein ligase binding
protein modification by small protein removal
regulation of autophagy