USP16 [The Human Chemical-Genetic Interaction Map Project]

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======= USP16 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: USP16
  * **<color #00a2e8>Official Name</color>**: ubiquitin specific peptidase 16
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10600|10600]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y5T5|Q9Y5T5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=USP16&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20USP16|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604735|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UCH|
|zf-UBP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone H2A K63-linked deubiquitination|
|monoubiquitinated histone deubiquitination|
|monoubiquitinated histone H2A deubiquitination|
|positive regulation of translational elongation|
|monoubiquitinated protein deubiquitination|
|regulation of translational elongation|
|histone deubiquitination|
|protein K63-linked deubiquitination|
|thiol-dependent ubiquitinyl hydrolase activity|
|ubiquitin binding|
|cysteine-type endopeptidase activity|
|protein homotetramerization|
|thiol-dependent ubiquitin-specific protease activity|
|positive regulation of translation|
|histone binding|
|mitotic nuclear division|
|protein tetramerization|
|positive regulation of cellular amide metabolic process|
|protein deubiquitination|
|transcription coactivator activity|
|nuclear division|
|protein modification by small protein removal|
|organelle fission|
|protein homooligomerization|
|regulation of translation|
|histone modification|
|covalent chromatin modification|
|regulation of cellular amide metabolic process|
|cell division|
|protein complex oligomerization|
|posttranscriptional regulation of gene expression|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|mitotic cell cycle process|
|cellular protein catabolic process|
|mitotic cell cycle|
|protein catabolic process|
|chromatin organization|
|cellular response to DNA damage stimulus|
|zinc ion binding|
|cellular macromolecule catabolic process|
|protein modification by small protein conjugation or removal|
|cell cycle process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|chromosome organization|
|regulation of cell cycle|
|positive regulation of transcription by RNA polymerase II|
|proteolysis|
|cell cycle|
|positive regulation of transcription, DNA-templated|
|protein-containing complex assembly|
|positive regulation of cellular protein metabolic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-2.06|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-1.8|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-1.78|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-1.77|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-1.71|
|[[:results:exp73|LJH685 5μM R02 exp73]]|-1.71|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-1.7|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|1.8|
|[[:results:exp210|LB-100 2μM R05 exp210]]|1.81|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.84|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|2.06|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|2.13|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.36|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|2.56|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16920
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='USP16 Expression in NALM6 Cells: 6.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>