USP16
Gene Information
- Official Symbol: USP16
- Official Name: ubiquitin specific peptidase 16
- Aliases and Previous Symbols: N/A
- Entrez ID: 10600
- UniProt: Q9Y5T5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| UCH |
| zf-UBP |
GO Terms
| histone H2A K63-linked deubiquitination |
| monoubiquitinated histone deubiquitination |
| monoubiquitinated histone H2A deubiquitination |
| positive regulation of translational elongation |
| monoubiquitinated protein deubiquitination |
| regulation of translational elongation |
| histone deubiquitination |
| protein K63-linked deubiquitination |
| thiol-dependent ubiquitinyl hydrolase activity |
| ubiquitin binding |
| cysteine-type endopeptidase activity |
| protein homotetramerization |
| thiol-dependent ubiquitin-specific protease activity |
| positive regulation of translation |
| histone binding |
| mitotic nuclear division |
| protein tetramerization |
| positive regulation of cellular amide metabolic process |
| protein deubiquitination |
| transcription coactivator activity |
| nuclear division |
| protein modification by small protein removal |
| organelle fission |
| protein homooligomerization |
| regulation of translation |
| histone modification |
| covalent chromatin modification |
| regulation of cellular amide metabolic process |
| cell division |
| protein complex oligomerization |
| posttranscriptional regulation of gene expression |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| modification-dependent macromolecule catabolic process |
| proteolysis involved in cellular protein catabolic process |
| mitotic cell cycle process |
| cellular protein catabolic process |
| mitotic cell cycle |
| protein catabolic process |
| chromatin organization |
| cellular response to DNA damage stimulus |
| zinc ion binding |
| cellular macromolecule catabolic process |
| protein modification by small protein conjugation or removal |
| cell cycle process |
| macromolecule catabolic process |
| organonitrogen compound catabolic process |
| chromosome organization |
| regulation of cell cycle |
| positive regulation of transcription by RNA polymerase II |
| proteolysis |
| cell cycle |
| positive regulation of transcription, DNA-templated |
| protein-containing complex assembly |
| positive regulation of cellular protein metabolic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| organic substance catabolic process |
| cellular catabolic process |
| protein-containing complex subunit organization |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 16920
- Expression level (log2 read counts): 6.43
Expression Distribution
USP16 Expression in NALM6 Cells: 6.43
