USP18

Entrez Summary: N/A
UniProt Summary: Involved in the regulation of inflammatory response to interferon type 1 (PubMed:27325888). Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds. Necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms. {ECO:0000269|PubMed:27325888}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 7/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	2/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	1/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of type I interferon-mediated signaling pathway
thiol-dependent ubiquitinyl hydrolase activity
cysteine-type endopeptidase activity
thiol-dependent ubiquitin-specific protease activity
regulation of cytokine-mediated signaling pathway
regulation of response to cytokine stimulus
protein deubiquitination
regulation of protein stability
protein modification by small protein removal
regulation of inflammatory response
regulation of innate immune response
regulation of response to biotic stimulus
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
regulation of defense response
regulation of multi-organism process
cellular macromolecule catabolic process
protein modification by small protein conjugation or removal
macromolecule catabolic process
organonitrogen compound catabolic process
regulation of response to external stimulus
regulation of immune response
proteolysis
regulation of response to stress
regulation of immune system process
organic substance catabolic process
cellular catabolic process