USP19 [The Human Chemical-Genetic Interaction Map Project]

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======= USP19 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: USP19
  * **<color #00a2e8>Official Name</color>**: ubiquitin specific peptidase 19
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10869|10869]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O94966|O94966]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=USP19&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20USP19|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614471|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This protein is a ubiquitin protein ligase and plays a role in muscle wasting. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF1872|
|UCH|
|zf-MYND|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of skeletal muscle tissue development|
|regulation of cellular response to hypoxia|
|Lys48-specific deubiquitinase activity|
|regulation of ERAD pathway|
|protein K48-linked deubiquitination|
|Hsp90 protein binding|
|negative regulation of striated muscle tissue development|
|negative regulation of muscle organ development|
|regulation of skeletal muscle tissue development|
|negative regulation of muscle tissue development|
|thiol-dependent ubiquitinyl hydrolase activity|
|negative regulation of proteasomal protein catabolic process|
|ubiquitin-dependent ERAD pathway|
|negative regulation of proteolysis involved in cellular protein catabolic process|
|regulation of response to endoplasmic reticulum stress|
|negative regulation of cellular protein catabolic process|
|ERAD pathway|
|thiol-dependent ubiquitin-specific protease activity|
|regulation of striated muscle tissue development|
|negative regulation of protein catabolic process|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|protein stabilization|
|regulation of proteasomal protein catabolic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|response to endoplasmic reticulum stress|
|protein deubiquitination|
|positive regulation of cell cycle process|
|regulation of protein stability|
|ubiquitin protein ligase binding|
|protein modification by small protein removal|
|negative regulation of catabolic process|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|negative regulation of proteolysis|
|positive regulation of cell cycle|
|regulation of protein catabolic process|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|regulation of proteolysis|
|regulation of cellular response to stress|
|regulation of cell cycle process|
|regulation of cellular catabolic process|
|cellular macromolecule catabolic process|
|endoplasmic reticulum membrane|
|negative regulation of developmental process|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|response to organonitrogen compound|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|proteolysis|
|regulation of response to stress|
|cellular response to stress|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|-2.14|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-1.85|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7475
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.54 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='USP19 Expression in NALM6 Cells: 6.54'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>