USP19

Gene Information

Official Symbol: USP19
Official Name: ubiquitin specific peptidase 19
Aliases and Previous Symbols: N/A
Entrez ID: 10869
UniProt: O94966
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This protein is a ubiquitin protein ligase and plays a role in muscle wasting. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7475
Expression level (log2 read counts): 6.54

Expression Distribution

Screen	Score
Isoniazid 100μM R08 exp494	-2.14
Mubritinib 0.2μM R01 exp48	-1.85
Nifuroxazide 5μM R03 exp102	1.85

DUF1872
UCH
zf-MYND

negative regulation of skeletal muscle tissue development
regulation of cellular response to hypoxia
Lys48-specific deubiquitinase activity
regulation of ERAD pathway
protein K48-linked deubiquitination
Hsp90 protein binding
negative regulation of striated muscle tissue development
negative regulation of muscle organ development
regulation of skeletal muscle tissue development
negative regulation of muscle tissue development
thiol-dependent ubiquitinyl hydrolase activity
negative regulation of proteasomal protein catabolic process
ubiquitin-dependent ERAD pathway
negative regulation of proteolysis involved in cellular protein catabolic process
regulation of response to endoplasmic reticulum stress
negative regulation of cellular protein catabolic process
ERAD pathway
thiol-dependent ubiquitin-specific protease activity
regulation of striated muscle tissue development
negative regulation of protein catabolic process
regulation of muscle tissue development
regulation of muscle organ development
protein stabilization
regulation of proteasomal protein catabolic process
regulation of proteolysis involved in cellular protein catabolic process
regulation of cellular protein catabolic process
negative regulation of cellular catabolic process
response to endoplasmic reticulum stress
protein deubiquitination
positive regulation of cell cycle process
regulation of protein stability
ubiquitin protein ligase binding
protein modification by small protein removal
negative regulation of catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
negative regulation of proteolysis
positive regulation of cell cycle
regulation of protein catabolic process
ubiquitin-dependent protein catabolic process