USP1 [The Human Chemical-Genetic Interaction Map Project]

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======= USP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: USP1
  * **<color #00a2e8>Official Name</color>**: ubiquitin specific peptidase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7398|7398]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O94782|O94782]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=USP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20USP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603478|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335). Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029). {ECO:0000269|PubMed:15694335, ECO:0000269|PubMed:16531995, ECO:0000269|PubMed:18082604, ECO:0000269|PubMed:26388029}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UCH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|monoubiquitinated protein deubiquitination|
|DNA damage response, detection of DNA damage|
|interstrand cross-link repair|
|thiol-dependent ubiquitinyl hydrolase activity|
|peptidase activity|
|cysteine-type endopeptidase activity|
|thiol-dependent ubiquitin-specific protease activity|
|regulation of DNA repair|
|response to UV|
|regulation of response to DNA damage stimulus|
|protein deubiquitination|
|protein modification by small protein removal|
|response to light stimulus|
|regulation of DNA metabolic process|
|response to radiation|
|skeletal system development|
|DNA repair|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|detection of stimulus|
|regulation of cellular response to stress|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|cellular macromolecule catabolic process|
|protein modification by small protein conjugation or removal|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|response to abiotic stimulus|
|proteolysis|
|regulation of response to stress|
|cellular response to stress|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.27|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-2.24|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-2.22|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-2.05|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-2.03|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-1.97|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-1.94|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-1.85|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-1.82|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|-1.81|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.8|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|-1.78|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-1.77|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-1.71|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.71|
|[[:results:exp115|A-366 10μM R03 exp115]]|1.86|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|1.96|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.02|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.23|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.49|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.64|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.99|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|3.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18642
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.57 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='USP1 Expression in NALM6 Cells: 7.57'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>