USP1

Entrez Summary: N/A
UniProt Summary: Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335). Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029). {ECO:0000269|PubMed:15694335, ECO:0000269|PubMed:16531995, ECO:0000269|PubMed:18082604, ECO:0000269|PubMed:26388029}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
TRAIL 50ng/ml R00 exp36	-2.27
TRAIL 5ng/ml R00 exp35	-2.24
Diepoxybutane 3μM R07 exp354	-2.22
Talazoparib 0.006μM R06 exp299	-2.05
GSK-J4 1.5μM R08 exp441	-2.03
Epothilone-B 0.0015μM R05 exp231	-1.97
Adefovir 20μM R07 exp332	-1.94
Nutlin-3A 1.6μM R06 exp294	-1.85
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-1.82
Curcumin 6.5μM R06 exp277	-1.81
Mdivi-1 15μM R05 exp217	-1.8
Daidzin 10μM R06 exp280	-1.78
Bisphenol S 100μM R08 exp458	-1.77
Lapatinib 5μM R01 exp47	-1.71
Vinblastine 0.002μM R01 exp60	-1.71
A-366 10μM R03 exp115	1.86
NN-Diethyl-meta-toluamide 500μM R08 exp438	1.96
MLN-4924 0.2μM R00 exp21	2.02
ML-792 0.2μM R08 exp505	2.23
Rapamycin 10μM R00 exp30	2.49
Trimetrexate 0.03μM R08 exp535	2.64
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.99
Hippuristanol 0.12μM R08 exp488	3.86

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	1/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

monoubiquitinated protein deubiquitination
DNA damage response, detection of DNA damage
interstrand cross-link repair
thiol-dependent ubiquitinyl hydrolase activity
peptidase activity
cysteine-type endopeptidase activity
thiol-dependent ubiquitin-specific protease activity
regulation of DNA repair
response to UV
regulation of response to DNA damage stimulus
protein deubiquitination
protein modification by small protein removal
response to light stimulus
regulation of DNA metabolic process
response to radiation
skeletal system development
DNA repair
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
detection of stimulus
regulation of cellular response to stress
DNA metabolic process
cellular response to DNA damage stimulus
cellular macromolecule catabolic process
protein modification by small protein conjugation or removal
macromolecule catabolic process
organonitrogen compound catabolic process
response to abiotic stimulus
proteolysis
regulation of response to stress
cellular response to stress
organic substance catabolic process
cellular catabolic process