USP22 [The Human Chemical-Genetic Interaction Map Project]

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======= USP22 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: USP22
  * **<color #00a2e8>Official Name</color>**: ubiquitin specific peptidase 22
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23326|23326]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UPT9|Q9UPT9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=USP22&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20USP22|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612116|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression. {ECO:0000269|PubMed:18206972, ECO:0000269|PubMed:18206973, ECO:0000269|PubMed:18469533}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-UBP|
|UCH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|SAGA-type complex|
|H4 histone acetyltransferase activity|
|SAGA complex|
|histone deubiquitination|
|histone ubiquitination|
|histone H4 acetylation|
|nuclear receptor transcription coactivator activity|
|thiol-dependent ubiquitin-specific protease activity|
|histone acetylation|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|protein acetylation|
|positive regulation of mitotic cell cycle|
|protein acylation|
|protein deubiquitination|
|transcription coactivator activity|
|protein modification by small protein removal|
|peptidyl-lysine modification|
|enzyme binding|
|histone modification|
|covalent chromatin modification|
|positive regulation of cell cycle|
|nuclear speck|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|regulation of mitotic cell cycle|
|embryo development ending in birth or egg hatching|
|protein catabolic process|
|protein ubiquitination|
|chromatin organization|
|protein modification by small protein conjugation|
|zinc ion binding|
|peptidyl-amino acid modification|
|cellular macromolecule catabolic process|
|embryo development|
|protein modification by small protein conjugation or removal|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|chromosome organization|
|regulation of cell cycle|
|proteolysis|
|cell cycle|
|positive regulation of transcription, DNA-templated|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-1.8|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.79|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-1.76|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-1.72|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.7|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.72|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.76|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|1.81|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.84|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.03|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.07|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|2.12|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.16|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|2.2|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|2.35|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|2.5|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:i:id3|ID3]]|0.542|
|[[:human genes:t:taf5l|TAF5L]]|0.517|
|[[:human genes:c:ccdc101|CCDC101]]|0.505|
|[[:human genes:s:supt7l|SUPT7L]]|0.501|
|[[:human genes:t:taf6l|TAF6L]]|0.468|
|[[:human genes:z:znf592|ZNF592]]|0.465|
|[[:human genes:m:med23|MED23]]|0.452|
|[[:human genes:k:kat2a|KAT2A]]|0.447|
|[[:human genes:m:mllt1|MLLT1]]|0.444|
|[[:human genes:t:tada2b|TADA2B]]|0.438|
|[[:human genes:h:hhex|HHEX]]|0.434|
|[[:human genes:n:nsd1|NSD1]]|0.432|
|[[:human genes:a:atxn7l3|ATXN7L3]]|0.431|
|[[:human genes:r:rptor|RPTOR]]|0.43|
|[[:human genes:m:manf|MANF]]|0.428|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.426|
|[[:human genes:b:brpf1|BRPF1]]|0.425|
|[[:human genes:o:otud5|OTUD5]]|0.42|
|[[:human genes:t:tada1|TADA1]]|0.419|
|[[:human genes:t:trim28|TRIM28]]|0.415|
|[[:human genes:w:wdr24|WDR24]]|0.412|
|[[:human genes:m:maml1|MAML1]]|0.411|
|[[:human genes:t:tle4|TLE4]]|0.405|
|[[:human genes:a:atxn7|ATXN7]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2933
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='USP22 Expression in NALM6 Cells: 8.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>