USP22

Entrez Summary: N/A
UniProt Summary: Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression. {ECO:0000269|PubMed:18206972, ECO:0000269|PubMed:18206973, ECO:0000269|PubMed:18469533}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
MK-1775 0.32μM R02 exp75	-1.8
Rapamycin 10μM R00 exp30	-1.79
Lapatinib 5μM R01 exp47	-1.76
Tubastatin-A 2.5μM R07 exp417	-1.72
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-1.7
Quercetin 20μM R08 exp517	1.72
LY2090314 0.003μM R08 exp499	1.76
JQ1 0.8μM R08 exp435	1.81
Actinomycin-D 0.001μM R00 exp3	1.84
Mdivi-1 15μM R05 exp217	2.03
UM131593 0.2μM R03 exp106	2.07
∆-9-Tetrahydrocannabinol 30μM R08 exp445	2.12
LY2090314 0.003μM R08 exp500 no dilution day6	2.16
Vincristine 0.0005μM R04 exp190	2.2
BI-2536 0.0042μM R03 exp95	2.35
Epothilone-B 0.0015μM R05 exp231	2.5

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

zf-UBP
UCH

SAGA-type complex
H4 histone acetyltransferase activity
SAGA complex
histone deubiquitination
histone ubiquitination
histone H4 acetylation
nuclear receptor transcription coactivator activity
thiol-dependent ubiquitin-specific protease activity
histone acetylation
internal peptidyl-lysine acetylation
peptidyl-lysine acetylation
internal protein amino acid acetylation
protein acetylation
positive regulation of mitotic cell cycle
protein acylation
protein deubiquitination
transcription coactivator activity
protein modification by small protein removal
peptidyl-lysine modification
enzyme binding
histone modification
covalent chromatin modification
positive regulation of cell cycle
nuclear speck
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
regulation of mitotic cell cycle
embryo development ending in birth or egg hatching
protein catabolic process
protein ubiquitination
chromatin organization
protein modification by small protein conjugation
zinc ion binding
peptidyl-amino acid modification
cellular macromolecule catabolic process
embryo development
protein modification by small protein conjugation or removal