USP39 [The Human Chemical-Genetic Interaction Map Project]

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======= USP39 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: USP39
  * **<color #00a2e8>Official Name</color>**: ubiquitin specific peptidase 39
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10713|10713]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q53GS9|Q53GS9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=USP39&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20USP39|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611594|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-UBP|
|UCH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|U4/U6 x U5 tri-snRNP complex|
|thiol-dependent ubiquitinyl hydrolase activity|
|spliceosomal complex assembly|
|spliceosomal complex|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|protein deubiquitination|
|protein modification by small protein removal|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|cell division|
|mRNA metabolic process|
|zinc ion binding|
|cellular protein-containing complex assembly|
|RNA processing|
|protein modification by small protein conjugation or removal|
|proteolysis|
|cell cycle|
|protein-containing complex assembly|
|RNA metabolic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp135|MS023 7μM R03 exp135]]|-2.73|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-2.04|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.97|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|1.76|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|1.78|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|1.88|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|1.94|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|1.95|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|1.96|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|2.15|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|2.3|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.34|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|2.45|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 11/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1544
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='USP39 Expression in NALM6 Cells: 6.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>