USP39

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 11/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	2/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Expression Distribution

zf-UBP
UCH

U4/U6 x U5 tri-snRNP complex
thiol-dependent ubiquitinyl hydrolase activity
spliceosomal complex assembly
spliceosomal complex
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
protein deubiquitination
protein modification by small protein removal
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions
RNA splicing
ribonucleoprotein complex biogenesis
mRNA processing
cell division
mRNA metabolic process
zinc ion binding
cellular protein-containing complex assembly
RNA processing
protein modification by small protein conjugation or removal
proteolysis
cell cycle
protein-containing complex assembly
RNA metabolic process
protein-containing complex subunit organization
gene expression