USP5 [The Human Chemical-Genetic Interaction Map Project]

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======= USP5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: USP5
  * **<color #00a2e8>Official Name</color>**: ubiquitin specific peptidase 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8078|8078]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P45974|P45974]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=USP5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20USP5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601447|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys- 63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition. {ECO:0000269|PubMed:19098288}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UCH|
|zf-UBP|
|UBA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein K48-linked deubiquitination|
|thiol-dependent ubiquitinyl hydrolase activity|
|ubiquitin binding|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|cysteine-type endopeptidase activity|
|positive regulation of ubiquitin-dependent protein catabolic process|
|positive regulation of proteasomal protein catabolic process|
|thiol-dependent ubiquitin-specific protease activity|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|positive regulation of cellular protein catabolic process|
|regulation of ubiquitin-dependent protein catabolic process|
|regulation of proteasomal protein catabolic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of protein catabolic process|
|regulation of cellular protein catabolic process|
|lysosome|
|protein deubiquitination|
|protein modification by small protein removal|
|positive regulation of proteolysis|
|positive regulation of cellular catabolic process|
|regulation of protein catabolic process|
|positive regulation of catabolic process|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|protein ubiquitination|
|regulation of proteolysis|
|protein modification by small protein conjugation|
|regulation of cellular catabolic process|
|zinc ion binding|
|cellular macromolecule catabolic process|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|proteolysis|
|positive regulation of cellular protein metabolic process|
|positive regulation of protein metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-2.75|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.74|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-2.63|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-2.49|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-2.42|
|[[:results:exp539|42°C R08 exp539]]|-2.01|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-2|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-2|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.92|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-1.91|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|-1.82|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-1.81|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-1.77|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-1.77|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.71|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|-1.71|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|-1.7|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nipbl|NIPBL]]|0.425|
|[[:human genes:c:chmp4b|CHMP4B]]|0.423|
|[[:human genes:m:mtch2|MTCH2]]|0.422|
|[[:human genes:p:psma6|PSMA6]]|0.411|
|[[:human genes:p:psmc1|PSMC1]]|0.41|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 717/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|27/28|
|bone|24/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|20/20|
|lung|72/75|
|lymphocyte|15/16|
|ovary|23/26|
|pancreas|22/24|
|peripheral nervous system|15/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 184
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.1 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='USP5 Expression in NALM6 Cells: 7.1'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>