USP6NL

Entrez Summary: N/A
UniProt Summary: Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex. {ECO:0000269|PubMed:11099046, ECO:0000269|PubMed:17562788, ECO:0000269|PubMed:17684057}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

retrograde transport, plasma membrane to Golgi
plasma membrane to endosome transport
regulation of Golgi organization
virion assembly
regulation of cilium assembly
trans-Golgi network membrane
activation of GTPase activity
Golgi organization
Rab GTPase binding
regulation of plasma membrane bounded cell projection assembly
viral life cycle
regulation of cell projection assembly
regulation of organelle assembly
cytoplasmic vesicle
GTPase activator activity
positive regulation of GTPase activity
endomembrane system organization
regulation of GTPase activity
regulation of plasma membrane bounded cell projection organization
viral process
regulation of cell projection organization
positive regulation of hydrolase activity
symbiotic process
interspecies interaction between organisms
regulation of cellular component biogenesis
intracellular protein transport
regulation of hydrolase activity
regulation of organelle organization
positive regulation of catalytic activity
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
positive regulation of molecular function
establishment of localization in cell
nitrogen compound transport
vesicle-mediated transport