UTRN [The Human Chemical-Genetic Interaction Map Project]

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======= UTRN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UTRN
  * **<color #00a2e8>Official Name</color>**: utrophin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7402|7402]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P46939|P46939]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UTRN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UTRN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/128240|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WW|
|efhand 1|
|Spectrin|
|efhand 2|
|ZZ|
|CH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|contractile ring|
|response to muscle inactivity involved in regulation of muscle adaptation|
|response to denervation involved in regulation of muscle adaptation|
|vinculin binding|
|response to muscle inactivity|
|response to inactivity|
|response to stimulus involved in regulation of muscle adaptation|
|dystrophin-associated glycoprotein complex|
|filopodium membrane|
|neuromuscular junction development|
|positive regulation of cell-matrix adhesion|
|cortical actin cytoskeleton|
|regulation of sodium ion transmembrane transporter activity|
|regulation of sodium ion transmembrane transport|
|filopodium|
|neuromuscular junction|
|regulation of muscle adaptation|
|regulation of sodium ion transport|
|sarcolemma|
|regulation of cell-matrix adhesion|
|positive regulation of cell-substrate adhesion|
|growth cone|
|integrin binding|
|postsynaptic membrane|
|actin filament binding|
|regulation of cell-substrate adhesion|
|regulation of muscle system process|
|muscle contraction|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|actin binding|
|synapse organization|
|regulation of transporter activity|
|muscle organ development|
|muscle system process|
|regulation of cation transmembrane transport|
|cytoskeleton|
|regulation of metal ion transport|
|positive regulation of cell adhesion|
|protein kinase binding|
|muscle structure development|
|regulation of ion transmembrane transport|
|cell junction|
|regulation of transmembrane transport|
|regulation of system process|
|protein-containing complex|
|regulation of cell adhesion|
|regulation of ion transport|
|zinc ion binding|
|regulation of transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-2.01|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.94|
|[[:results:exp302|35°C R06 exp302]]|1.81|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.85|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.85|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|2.06|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11275
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UTRN Expression in NALM6 Cells: 8.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>