UTRN

Entrez Summary: This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008].
UniProt Summary: May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

contractile ring
response to muscle inactivity involved in regulation of muscle adaptation
response to denervation involved in regulation of muscle adaptation
vinculin binding
response to muscle inactivity
response to inactivity
response to stimulus involved in regulation of muscle adaptation
dystrophin-associated glycoprotein complex
filopodium membrane
neuromuscular junction development
positive regulation of cell-matrix adhesion
cortical actin cytoskeleton
regulation of sodium ion transmembrane transporter activity
regulation of sodium ion transmembrane transport
filopodium
neuromuscular junction
regulation of muscle adaptation
regulation of sodium ion transport
sarcolemma
regulation of cell-matrix adhesion
positive regulation of cell-substrate adhesion
growth cone
integrin binding
postsynaptic membrane
actin filament binding
regulation of cell-substrate adhesion
regulation of muscle system process
muscle contraction
regulation of ion transmembrane transporter activity
regulation of transmembrane transporter activity
actin binding
synapse organization
regulation of transporter activity
muscle organ development
muscle system process
regulation of cation transmembrane transport
cytoskeleton
regulation of metal ion transport
positive regulation of cell adhesion
protein kinase binding