VANGL2

Gene Information

Official Symbol: VANGL2
Official Name: VANGL planar cell polarity protein 2
Aliases and Previous Symbols: N/A
Entrez ID: 57216
UniProt: Q9ULK5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate. [provided by RefSeq, Sep 2011].
UniProt Summary: Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear (By similarity). {ECO:0000250|UniProtKB:Q91ZD4}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9049
Expression level (log2 read counts): 2.9

Expression Distribution

non-canonical Wnt signaling pathway involved in heart development
lateral sprouting involved in lung morphogenesis
cell migration involved in kidney development
planar dichotomous subdivision of terminal units involved in lung branching morphogenesis
orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis
cell pole
planar cell polarity pathway involved in heart morphogenesis
establishment of planar polarity involved in neural tube closure
neural plate elongation
convergent extension involved in neural plate elongation
dichotomous subdivision of terminal units involved in lung branching
planar cell polarity pathway involved in axis elongation
establishment of body hair or bristle planar orientation
serotonergic neuron axon guidance
establishment of body hair planar orientation
dopaminergic neuron axon guidance
Wnt signaling pathway involved in heart development
planar cell polarity pathway involved in axon guidance
establishment of planar polarity of embryonic epithelium
convergent extension involved in axis elongation
convergent extension involved in organogenesis
muscular septum morphogenesis
neural plate morphogenesis
convergent extension involved in gastrulation
lateral sprouting from an epithelium
membranous septum morphogenesis
neural plate development
dichotomous subdivision of an epithelial terminal unit
apical protein localization
planar cell polarity pathway involved in neural tube closure
convergent extension
regulation of establishment of planar polarity involved in neural tube closure
regulation of epithelial tube formation
post-anal tail morphogenesis
establishment of planar polarity
somatic stem cell division
establishment of tissue polarity
cochlea morphogenesis
cell surface receptor signaling pathway involved in heart development
epithelial tube branching involved in lung morphogenesis