VAPA [The Human Chemical-Genetic Interaction Map Project]

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======= VAPA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VAPA
  * **<color #00a2e8>Official Name</color>**: VAMP associated protein A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9218|9218]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P0L0|Q9P0L0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VAPA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VAPA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605703|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:25447204). With OSBPL3, may regulate ER morphology (PubMed:16143324). May play a role in vesicle trafficking (PubMed:11511104, PubMed:19289470). {ECO:0000269|PubMed:11511104, ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:19289470, ECO:0000269|PubMed:25447204}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Motile Sperm|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|FFAT motif binding|
|positive regulation by host of viral release from host cell|
|modulation by host of viral release from host cell|
|negative regulation by host of viral genome replication|
|positive regulation by host of viral genome replication|
|negative regulation by host of viral process|
|modulation by host of viral genome replication|
|positive regulation of viral release from host cell|
|positive regulation by host of viral process|
|protein folding in endoplasmic reticulum|
|modulation by host of viral process|
|endoplasmic reticulum exit site|
|regulation of viral release from host cell|
|positive regulation of viral genome replication|
|endoplasmic reticulum organization|
|negative regulation of viral genome replication|
|azurophil granule membrane|
|positive regulation of viral life cycle|
|COPII-coated vesicle budding|
|modification by host of symbiont morphology or physiology|
|interaction with symbiont|
|Golgi vesicle budding|
|negative regulation of viral life cycle|
|sphingolipid biosynthetic process|
|regulation of viral genome replication|
|vesicle budding from membrane|
|negative regulation of viral process|
|positive regulation of viral process|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|bicellular tight junction|
|membrane lipid biosynthetic process|
|membrane fusion|
|protein localization to endoplasmic reticulum|
|vesicle|
|regulation of viral life cycle|
|microtubule cytoskeleton|
|sphingolipid metabolic process|
|modification of morphology or physiology of other organism|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|membrane lipid metabolic process|
|regulation of viral process|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|negative regulation of multi-organism process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|protein folding|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|nuclear membrane|
|microtubule binding|
|protein domain specific binding|
|vesicle organization|
|cadherin binding|
|Golgi vesicle transport|
|endomembrane system organization|
|neutrophil degranulation|
|protein heterodimerization activity|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|positive regulation of multi-organism process|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|positive regulation of locomotion|
|lipid biosynthetic process|
|myeloid leukocyte activation|
|Golgi membrane|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|neuron projection development|
|perinuclear region of cytoplasm|
|regulated exocytosis|
|protein localization to organelle|
|leukocyte mediated immunity|
|regulation of multi-organism process|
|symbiotic process|
|exocytosis|
|neuron development|
|interspecies interaction between organisms|
|membrane organization|
|leukocyte activation|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|regulation of locomotion|
|secretion by cell|
|neuron differentiation|
|endoplasmic reticulum|
|positive regulation of intracellular signal transduction|
|export from cell|
|cell activation|
|immune effector process|
|cell death|
|secretion|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|lipid metabolic process|
|organonitrogen compound biosynthetic process|
|intracellular transport|
|generation of neurons|
|cellular protein localization|
|cellular macromolecule localization|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.79|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|-2.06|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-2.06|
|[[:results:exp169|BH1 1μM R04 exp169]]|-1.93|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.91|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.91|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-1.9|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-1.88|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-1.77|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|1.73|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|1.8|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|1.81|
|[[:results:exp433|LJH685 50μM R08 exp433]]|1.81|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.84|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.15|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.3|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|2.51|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mbtps1|MBTPS1]]|0.464|
|[[:human genes:s:scap|SCAP]]|0.421|
|[[:human genes:m:mbtps2|MBTPS2]]|0.419|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3985
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VAPA Expression in NALM6 Cells: 6.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>