VAPA

Gene Information

Official Symbol: VAPA
Official Name: VAMP associated protein A
Aliases and Previous Symbols: N/A
Entrez ID: 9218
UniProt: Q9P0L0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:25447204). With OSBPL3, may regulate ER morphology (PubMed:16143324). May play a role in vesicle trafficking (PubMed:11511104, PubMed:19289470). {ECO:0000269|PubMed:11511104, ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:19289470, ECO:0000269|PubMed:25447204}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Clomiphene 4.4μM R02 exp68	-2.79
Cyclosporin-A 3μM R07 exp348	-2.06
Fluvastatin 2.2μM R06 exp282	-2.06
BH1 1μM R04 exp169	-1.93
THZ531 0.11 to 0.175μM on day4 R07 exp413	-1.91
THZ531 0.225μM R08 exp444	-1.91
Thioridazine 5μM R08 exp530	-1.9
Azithromycin 100μM R08 exp452	-1.88
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-1.77
Pimelic-diphenylamide-106 5μM R00 exp28	1.73
Lead acetate 2000μM R08 exp497	1.8
Lead acetate 2000μM R08 exp498 no dilution day6	1.81
LJH685 50μM R08 exp433	1.81
Arsenate 40μM R06 exp264	1.84
Thimerosal 0.85μM R08 exp529	2.15
VER-155008 3.9μM R06 exp301	2.3
BML-284 0.09μM R08 exp460	2.51

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3985
Expression level (log2 read counts): 6.73

Expression Distribution

Gene	Correlation
MBTPS1	0.464
SCAP	0.421
MBTPS2	0.419

FFAT motif binding
positive regulation by host of viral release from host cell
modulation by host of viral release from host cell
negative regulation by host of viral genome replication
positive regulation by host of viral genome replication
negative regulation by host of viral process
modulation by host of viral genome replication
positive regulation of viral release from host cell
positive regulation by host of viral process
protein folding in endoplasmic reticulum
modulation by host of viral process
endoplasmic reticulum exit site
regulation of viral release from host cell
positive regulation of viral genome replication
endoplasmic reticulum organization
negative regulation of viral genome replication
azurophil granule membrane
positive regulation of viral life cycle
COPII-coated vesicle budding
modification by host of symbiont morphology or physiology
interaction with symbiont
Golgi vesicle budding
negative regulation of viral life cycle
sphingolipid biosynthetic process
regulation of viral genome replication
vesicle budding from membrane
negative regulation of viral process
positive regulation of viral process
modification of morphology or physiology of other organism involved in symbiotic interaction
bicellular tight junction
membrane lipid biosynthetic process
membrane fusion
protein localization to endoplasmic reticulum
vesicle
regulation of viral life cycle
microtubule cytoskeleton
sphingolipid metabolic process
modification of morphology or physiology of other organism
positive regulation of I-kappaB kinase/NF-kappaB signaling
membrane lipid metabolic process