VAPB

Entrez Summary: The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking. [provided by RefSeq, Jul 2008].
UniProt Summary: Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation. {ECO:0000269|PubMed:16891305, ECO:0000269|PubMed:20940299, ECO:0000269|PubMed:22131369}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
MK-1775 0.32μM R02 exp75	1.79
Lenalidomide 20μM R07 exp375	1.8

FFAT motif binding
endoplasmic reticulum membrane organization
endoplasmic reticulum-plasma membrane tethering
endoplasmic reticulum localization
endoplasmic reticulum exit site
modulation by virus of host morphology or physiology
positive regulation of viral genome replication
beta-tubulin binding
modification by symbiont of host morphology or physiology
IRE1-mediated unfolded protein response
endoplasmic reticulum organization
positive regulation of viral life cycle
COPII-coated vesicle budding
Golgi vesicle budding
sphingolipid biosynthetic process
regulation of viral genome replication
vesicle budding from membrane
endoplasmic reticulum unfolded protein response
positive regulation of viral process
modification of morphology or physiology of other organism involved in symbiotic interaction
cellular response to unfolded protein
membrane lipid biosynthetic process
regulation of viral life cycle
cellular response to topologically incorrect protein
sphingolipid metabolic process
modification of morphology or physiology of other organism
interaction with host
response to unfolded protein
organelle localization by membrane tethering
membrane docking
response to topologically incorrect protein
membrane lipid metabolic process
regulation of viral process
endoplasmic reticulum to Golgi vesicle-mediated transport
regulation of symbiosis, encompassing mutualism through parasitism
microtubule binding
response to endoplasmic reticulum stress
vesicle organization
cadherin binding
enzyme binding