VAV2

Gene Information

Official Symbol: VAV2
Official Name: vav guanine nucleotide exchange factor 2
Aliases and Previous Symbols: N/A
Entrez ID: 7410
UniProt: P52735
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7660
Expression level (log2 read counts): -1.0

Expression Distribution

Screen	Score
EPZ-5676 30μM R05 exp233	1.84
LY2090314 0.003μM R08 exp500 no dilution day6	1.93

PH
SH3 1
CAMSAP CH
CH
SH3 2
SH2
C1 1
RhoGEF

positive regulation of phosphatidylinositol 3-kinase activity
epidermal growth factor receptor binding
lamellipodium assembly
positive regulation of lipid kinase activity
phosphotyrosine residue binding
lamellipodium organization
positive regulation of phospholipid metabolic process
regulation of phosphatidylinositol 3-kinase activity
regulation of lipid kinase activity
vascular endothelial growth factor receptor signaling pathway
Rho guanyl-nucleotide exchange factor activity
regulation of phospholipid metabolic process
ephrin receptor signaling pathway
guanyl-nucleotide exchange factor activity
immune response-regulating cell surface receptor signaling pathway involved in phagocytosis
Fc-gamma receptor signaling pathway involved in phagocytosis
Fc receptor mediated stimulatory signaling pathway
platelet activation
Fc-gamma receptor signaling pathway
positive regulation of lipid metabolic process
regulation of Rho protein signal transduction
Fc-epsilon receptor signaling pathway
regulation of cell size
Fc receptor signaling pathway
regulation of Ras protein signal transduction
blood coagulation
coagulation
hemostasis
angiogenesis
small GTPase mediated signal transduction
phagocytosis
regulation of small GTPase mediated signal transduction
regulation of cellular component size
regulation of lipid metabolic process
blood vessel morphogenesis
plasma membrane bounded cell projection assembly
immune response-activating cell surface receptor signaling pathway
cell projection assembly
wound healing
immune response-regulating cell surface receptor signaling pathway