VBP1 [The Human Chemical-Genetic Interaction Map Project]

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======= VBP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VBP1
  * **<color #00a2e8>Official Name</color>**: VHL binding protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7411|7411]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61758|P61758]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VBP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VBP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300133|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene interacts with the Von Hippel-Lindau protein to form an intracellular complex. The encoded protein functions as a chaperone protein, and may play a role in the transport of the Von Hippel-Lindau protein from the perinuclear granules to the nucleus or cytoplasm. Alternative splicing and the use of alternate transcription start sites results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Jan 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. {ECO:0000269|PubMed:9630229}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Prefoldin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|prefoldin complex|
|tubulin complex assembly|
|polysome|
|tubulin binding|
|protein folding|
|microtubule-based process|
|intracellular membrane-bounded organelle|
|cellular protein-containing complex assembly|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-3.68|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-2.85|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-2.79|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-2.78|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-2.73|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.65|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-2.62|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-2.61|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-2.53|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|-2.28|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-2.15|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-2.14|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-2.12|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-2.01|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-1.91|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-1.82|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.81|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-1.71|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|3.37|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|5.64|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pfdn5|PFDN5]]|0.702|
|[[:human genes:p:pfdn4|PFDN4]]|0.6|
|[[:human genes:p:pfdn1|PFDN1]]|0.528|
|[[:human genes:p:pdcd5|PDCD5]]|0.515|
|[[:human genes:s:ska1|SKA1]]|0.507|
|[[:human genes:t:tcp1|TCP1]]|0.5|
|[[:human genes:s:sssca1|SSSCA1]]|0.479|
|[[:human genes:k:kifc1|KIFC1]]|0.445|
|[[:human genes:t:tubb4b|TUBB4B]]|0.437|
|[[:human genes:t:tuba1b|TUBA1B]]|0.437|
|[[:human genes:a:arl2|ARL2]]|0.408|
|[[:human genes:k:kif15|KIF15]]|0.401|
|[[:human genes:h:h2afb1|H2AFB1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 306/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|11/28|
|blood|6/26|
|bone|10/26|
|breast|7/30|
|central nervous system|26/49|
|cervix|3/4|
|colorectal|8/17|
|esophagus|5/11|
|fibroblast|1/1|
|gastric|4/14|
|kidney|8/18|
|liver|8/19|
|lung|23/72|
|lymphocyte|3/16|
|ovary|12/25|
|pancreas|14/22|
|peripheral nervous system|4/15|
|plasma cell|2/12|
|prostate|0/1|
|skin|11/20|
|soft tissue|5/9|
|thyroid|1/2|
|upper aerodigestive|18/22|
|urinary tract|19/28|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13679
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VBP1 Expression in NALM6 Cells: 5.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>