VBP1

Entrez Summary: The protein encoded by this gene interacts with the Von Hippel-Lindau protein to form an intracellular complex. The encoded protein functions as a chaperone protein, and may play a role in the transport of the Von Hippel-Lindau protein from the perinuclear granules to the nucleus or cytoplasm. Alternative splicing and the use of alternate transcription start sites results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Jan 2015].
UniProt Summary: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. {ECO:0000269|PubMed:9630229}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Colchicine 0.009μM R05 exp215	-3.68
BI-6727 0.0125μM R03 exp97	-2.85
Sulforaphane 9μM R08 exp526 no dilution day6	-2.79
BI-2536 0.0042μM R03 exp95	-2.78
Demecolcine 0.03μM R05 exp228	-2.73
BML-284 0.09μM R08 exp460	-2.65
Vincristine 0.0005μM R04 exp190	-2.62
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-2.61
Sulforaphane 9μM R08 exp525	-2.53
Arsenic trioxide 60μM R08 exp449	-2.28
GSK461364A 0.005μM R03 exp125	-2.15
S-trityl-L-cysteine 0.5μM R05 exp243	-2.14
GSK626616 14μM R08 exp485	-2.12
Lead acetate 2000μM R08 exp498 no dilution day6	-2.01
Latrunculin-B 10μM R07 exp374	-1.91
Cytochalasin-B 5μM R07 exp349	-1.82
Thimerosal 0.85μM R08 exp529	-1.81
Pomalidomide 20μM R07 exp391	-1.71
Taxol 0.004μM R03 exp103	3.37
Epothilone-B 0.0015μM R05 exp231	5.64

Global Fraction of Cell Lines Where Essential: 306/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	11/28
blood	6/26
bone	10/26
breast	7/30
central nervous system	26/49
cervix	3/4
colorectal	8/17
esophagus	5/11
fibroblast	1/1
gastric	4/14
kidney	8/18
liver	8/19
lung	23/72
lymphocyte	3/16
ovary	12/25
pancreas	14/22
peripheral nervous system	4/15
plasma cell	2/12
prostate	0/1
skin	11/20
soft tissue	5/9
thyroid	1/2
upper aerodigestive	18/22
urinary tract	19/28
uterus	1/5

Expression Distribution

prefoldin complex
tubulin complex assembly
polysome
tubulin binding
protein folding
microtubule-based process
intracellular membrane-bounded organelle
cellular protein-containing complex assembly
protein-containing complex assembly
protein-containing complex subunit organization