VCAM1

Entrez Summary: This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010].
UniProt Summary: Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cardiac neuron differentiation
alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex
cell-cell adhesion in response to extracellular stimulus
membrane to membrane docking
primary amine oxidase activity
chronic inflammatory response
leukocyte tethering or rolling
leukocyte adhesion to vascular endothelial cell
calcium-mediated signaling using intracellular calcium source
innervation
podosome
heterotypic cell-cell adhesion
cellular response to amyloid-beta
cellular extravasation
cellular response to vascular endothelial growth factor stimulus
autonomic nervous system development
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
response to amyloid-beta
response to nicotine
leukocyte cell-cell adhesion
response to zinc ion
cell adhesion molecule binding
microvillus
amine metabolic process
acute inflammatory response
apical part of cell
interferon-gamma-mediated signaling pathway
filopodium
nerve development
positive regulation of T cell proliferation
sarcolemma
B cell differentiation
cardiocyte differentiation
response to ethanol
cell-matrix adhesion
positive regulation of lymphocyte proliferation
positive regulation of mononuclear cell proliferation
integrin binding
positive regulation of leukocyte proliferation
calcium-mediated signaling