VCAN [The Human Chemical-Genetic Interaction Map Project]

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======= VCAN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VCAN
  * **<color #00a2e8>Official Name</color>**: versican
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1462|1462]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P13611|P13611]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VCAN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VCAN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/118661|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sushi|
|Lectin C|
|EGF|
|V-set|
|Xlink|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dermatan sulfate biosynthetic process|
|dermatan sulfate metabolic process|
|chondroitin sulfate catabolic process|
|dermatan sulfate proteoglycan biosynthetic process|
|dermatan sulfate proteoglycan metabolic process|
|extracellular matrix structural constituent conferring compression resistance|
|hyaluronic acid binding|
|glycosaminoglycan binding|
|chondroitin sulfate biosynthetic process|
|chondroitin sulfate proteoglycan biosynthetic process|
|chondroitin sulfate metabolic process|
|chondroitin sulfate proteoglycan metabolic process|
|sulfur compound catabolic process|
|glycosaminoglycan catabolic process|
|aminoglycan catabolic process|
|proteoglycan biosynthetic process|
|proteoglycan metabolic process|
|lysosomal lumen|
|Golgi lumen|
|glycosaminoglycan biosynthetic process|
|mucopolysaccharide metabolic process|
|aminoglycan biosynthetic process|
|osteoblast differentiation|
|glycosaminoglycan metabolic process|
|aminoglycan metabolic process|
|carbohydrate binding|
|sulfur compound biosynthetic process|
|monocarboxylic acid biosynthetic process|
|carbohydrate derivative catabolic process|
|extracellular matrix|
|cell recognition|
|ossification|
|carboxylic acid biosynthetic process|
|endoplasmic reticulum lumen|
|organic acid biosynthetic process|
|glycoprotein biosynthetic process|
|extracellular matrix organization|
|post-translational protein modification|
|collagen-containing extracellular matrix|
|sulfur compound metabolic process|
|glycoprotein metabolic process|
|extracellular structure organization|
|skeletal system development|
|drug metabolic process|
|monocarboxylic acid metabolic process|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|calcium ion binding|
|carboxylic acid metabolic process|
|cell adhesion|
|biological adhesion|
|central nervous system development|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|organonitrogen compound biosynthetic process|
|extracellular space|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|extracellular region|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15812
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VCAN Expression in NALM6 Cells: -0.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>