VCAN

Entrez Summary: This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009].
UniProt Summary: May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

dermatan sulfate biosynthetic process
dermatan sulfate metabolic process
chondroitin sulfate catabolic process
dermatan sulfate proteoglycan biosynthetic process
dermatan sulfate proteoglycan metabolic process
extracellular matrix structural constituent conferring compression resistance
hyaluronic acid binding
glycosaminoglycan binding
chondroitin sulfate biosynthetic process
chondroitin sulfate proteoglycan biosynthetic process
chondroitin sulfate metabolic process
chondroitin sulfate proteoglycan metabolic process
sulfur compound catabolic process
glycosaminoglycan catabolic process
aminoglycan catabolic process
proteoglycan biosynthetic process
proteoglycan metabolic process
lysosomal lumen
Golgi lumen
glycosaminoglycan biosynthetic process
mucopolysaccharide metabolic process
aminoglycan biosynthetic process
osteoblast differentiation
glycosaminoglycan metabolic process
aminoglycan metabolic process
carbohydrate binding
sulfur compound biosynthetic process
monocarboxylic acid biosynthetic process
carbohydrate derivative catabolic process
extracellular matrix
cell recognition
ossification
carboxylic acid biosynthetic process
endoplasmic reticulum lumen
organic acid biosynthetic process
glycoprotein biosynthetic process
extracellular matrix organization
post-translational protein modification
collagen-containing extracellular matrix
sulfur compound metabolic process