VEGFA

Gene Information

Official Symbol: VEGFA
Official Name: vascular endothelial growth factor A
Aliases and Previous Symbols: N/A
Entrez ID: 7422
UniProt: P15692
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. [provided by RefSeq, Nov 2015].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5584
Expression level (log2 read counts): 5.56

Expression Distribution

regulation of protein kinase D signaling
positive regulation of protein kinase D signaling
negative regulation of establishment of endothelial barrier
VEGF-activated neuropilin signaling pathway
positive regulation of retinal ganglion cell axon guidance
primitive erythrocyte differentiation
coronary vein morphogenesis
cellular stress response to acid chemical
negative regulation of endothelial cell development
stress response to acid chemical
vascular endothelial growth factor receptor 1 binding
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
VEGF-activated platelet-derived growth factor receptor signaling pathway
cardiac vascular smooth muscle cell development
neuropilin signaling pathway
positive regulation of peptidyl-tyrosine autophosphorylation
regulation of peptidyl-tyrosine autophosphorylation
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
regulation of retinal ganglion cell axon guidance
primitive hemopoiesis
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
motor neuron migration
positive regulation of mast cell chemotaxis
positive regulation of histone deacetylase activity
cardiac vascular smooth muscle cell differentiation
vascular endothelial growth factor receptor binding
regulation of mast cell chemotaxis
positive regulation of axon extension involved in axon guidance
post-embryonic camera-type eye development
positive regulation of cell migration by vascular endothelial growth factor signaling pathway
positive regulation of axon guidance
positive regulation of deacetylase activity
negative regulation of cell-cell adhesion mediated by cadherin
vascular endothelial growth factor receptor 2 binding
negative regulation of endothelial cell differentiation
endothelial cell chemotaxis
venous blood vessel morphogenesis
regulation of histone deacetylase activity
coronary artery morphogenesis
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis