VEZF1 [The Human Chemical-Genetic Interaction Map Project]

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======= VEZF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VEZF1
  * **<color #00a2e8>Official Name</color>**: vascular endothelial zinc finger 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7716|7716]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14119|Q14119]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VEZF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VEZF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606747|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Possible transcription factor. Specifically binds to the CT/GC-rich region of the interleukin-3 promoter and mediates tax transactivation of IL-3. {ECO:0000269|PubMed:8035792}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of endothelial cell differentiation|
|regulation of endothelial cell differentiation|
|endothelial cell development|
|cellular defense response|
|positive regulation of epithelial cell differentiation|
|endothelial cell differentiation|
|endothelium development|
|regulation of epithelial cell differentiation|
|epithelial cell development|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|angiogenesis|
|blood vessel morphogenesis|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|transcription by RNA polymerase II|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|tube morphogenesis|
|epithelial cell differentiation|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|positive regulation of cell differentiation|
|nucleobase-containing compound biosynthetic process|
|epithelium development|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of transcription by RNA polymerase II|
|organic cyclic compound biosynthetic process|
|defense response|
|positive regulation of developmental process|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|tissue development|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.45|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-2.33|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-2.28|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-2.11|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-1.82|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-1.81|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|-1.79|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.77|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|1.77|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|1.84|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.9|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.11|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|2.19|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|2.5|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.62|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tgif1|TGIF1]]|0.506|
|[[:human genes:s:syk|SYK]]|0.497|
|[[:human genes:r:rhoh|RHOH]]|0.495|
|[[:human genes:m:mapkap1|MAPKAP1]]|0.472|
|[[:human genes:p:pik3cd|PIK3CD]]|0.463|
|[[:human genes:r:rbm7|RBM7]]|0.459|
|[[:human genes:r:rictor|RICTOR]]|0.456|
|[[:human genes:c:cd79a|CD79A]]|0.453|
|[[:human genes:c:cd19|CD19]]|0.436|
|[[:human genes:p:pdcl|PDCL]]|0.43|
|[[:human genes:i:igll1|IGLL1]]|0.427|
|[[:human genes:c:crebbp|CREBBP]]|0.407|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3587
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VEZF1 Expression in NALM6 Cells: 6.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>