VEZF1

Entrez Summary: N/A
UniProt Summary: Possible transcription factor. Specifically binds to the CT/GC-rich region of the interleukin-3 promoter and mediates tax transactivation of IL-3. {ECO:0000269|PubMed:8035792}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
TRAIL 50ng/ml R00 exp36	-2.45
Thapsigargin 0.005μM R07 exp407	-2.33
Pimelic-diphenylamide-106 5μM R00 exp28	-2.28
Wortmannin 5μM R00 exp38	-2.11
Q15 1 to 2μM on day4 R04 exp164	-1.82
Epothilone-B 0.0015μM R05 exp231	-1.81
Dexamethasone 0.006μM R07 exp351	-1.79
Arsenate 40μM R06 exp264	1.77
YM155 0.001μM R08 exp432	1.77
THZ531 0.11 to 0.125μM on day4 R07 exp410	1.84
Hippuristanol 0.12μM R08 exp488	1.9
Mubritinib 0.2μM R01 exp48	2.11
Nicotine 3000μM R08 exp510	2.19
Nifuroxazide 5μM R03 exp102	2.5
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.62

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of endothelial cell differentiation
regulation of endothelial cell differentiation
endothelial cell development
cellular defense response
positive regulation of epithelial cell differentiation
endothelial cell differentiation
endothelium development
regulation of epithelial cell differentiation
epithelial cell development
RNA polymerase II regulatory region sequence-specific DNA binding
angiogenesis
blood vessel morphogenesis
DNA-binding transcription activator activity, RNA polymerase II-specific
transcription by RNA polymerase II
blood vessel development
vasculature development
cardiovascular system development
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
tube morphogenesis
epithelial cell differentiation
tube development
circulatory system development
anatomical structure formation involved in morphogenesis
positive regulation of cell differentiation
nucleobase-containing compound biosynthetic process
epithelium development
heterocycle biosynthetic process
aromatic compound biosynthetic process
positive regulation of transcription by RNA polymerase II
organic cyclic compound biosynthetic process
defense response
positive regulation of developmental process
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
cellular nitrogen compound biosynthetic process
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
cell development