VMP1 [The Human Chemical-Genetic Interaction Map Project]

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======= VMP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VMP1
  * **<color #00a2e8>Official Name</color>**: vacuole membrane protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=81671|81671]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96GC9|Q96GC9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VMP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VMP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611753|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a transmembrane protein that plays a key regulatory role in the process of autophagy. The ectopic overexpression of the encoded protein in cultured cells triggers autophagy even under nutrient-rich conditions. This gene is overexpressed in pancreatitis affected acinar cells where the encoded protein mediates sequestration and degradation of potentially deleterious activated zymogen granules in a process termed, zymophagy. [provided by RefSeq, Jul 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Plays a role in the initial stages of the autophagic process through its interaction with BECN1 (By similarity). Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions. {ECO:0000250, ECO:0000269|PubMed:17724469}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SNARE assoc|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phagophore assembly site|
|autophagosome membrane|
|embryo implantation|
|autophagosome assembly|
|autophagosome organization|
|endoplasmic reticulum-Golgi intermediate compartment membrane|
|vacuole organization|
|Golgi organization|
|macroautophagy|
|cell junction assembly|
|female pregnancy|
|multi-multicellular organism process|
|cell junction organization|
|process utilizing autophagic mechanism|
|autophagy|
|endomembrane system organization|
|cell-cell adhesion|
|organelle assembly|
|nucleolus|
|cell adhesion|
|biological adhesion|
|multi-organism reproductive process|
|endoplasmic reticulum|
|reproductive process|
|reproduction|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-1.74|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-1.72|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.71|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|1.72|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|1.85|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.91|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:med16|MED16]]|0.533|
|[[:human genes:m:mllt1|MLLT1]]|0.529|
|[[:human genes:d:dpagt1|DPAGT1]]|0.524|
|[[:human genes:h:hars|HARS]]|0.523|
|[[:human genes:p:pam16|PAM16]]|0.519|
|[[:human genes:g:gnb1l|GNB1L]]|0.519|
|[[:human genes:g:gfpt1|GFPT1]]|0.518|
|[[:human genes:p:pmm2|PMM2]]|0.516|
|[[:human genes:r:rptor|RPTOR]]|0.515|
|[[:human genes:r:rnmt|RNMT]]|0.51|
|[[:human genes:t:tmem41b|TMEM41B]]|0.508|
|[[:human genes:c:cbfb|CBFB]]|0.504|
|[[:human genes:a:alg5|ALG5]]|0.503|
|[[:human genes:a:alg2|ALG2]]|0.503|
|[[:human genes:d:dnajc3|DNAJC3]]|0.502|
|[[:human genes:c:ccdc101|CCDC101]]|0.499|
|[[:human genes:a:alg1|ALG1]]|0.493|
|[[:human genes:d:dohh|DOHH]]|0.49|
|[[:human genes:x:xpo6|XPO6]]|0.484|
|[[:human genes:m:med23|MED23]]|0.484|
|[[:human genes:t:tti1|TTI1]]|0.481|
|[[:human genes:p:polr3h|POLR3H]]|0.476|
|[[:human genes:r:rtcb|RTCB]]|0.469|
|[[:human genes:u:ube2g2|UBE2G2]]|0.469|
|[[:human genes:t:triap1|TRIAP1]]|0.464|
|[[:human genes:a:aars|AARS]]|0.46|
|[[:human genes:u:ube2j1|UBE2J1]]|0.456|
|[[:human genes:w:wdr24|WDR24]]|0.455|
|[[:human genes:a:atp2a2|ATP2A2]]|0.455|
|[[:human genes:m:mtor|MTOR]]|0.453|
|[[:human genes:p:polr3b|POLR3B]]|0.453|
|[[:human genes:m:manf|MANF]]|0.453|
|[[:human genes:t:tti2|TTI2]]|0.452|
|[[:human genes:o:otud5|OTUD5]]|0.452|
|[[:human genes:t:trmt5|TRMT5]]|0.451|
|[[:human genes:g:gmppb|GMPPB]]|0.45|
|[[:human genes:t:thg1l|THG1L]]|0.45|
|[[:human genes:s:srp72|SRP72]]|0.446|
|[[:human genes:t:tle4|TLE4]]|0.446|
|[[:human genes:p:pelo|PELO]]|0.443|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.443|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.443|
|[[:human genes:d:dhdds|DHDDS]]|0.443|
|[[:human genes:m:meaf6|MEAF6]]|0.442|
|[[:human genes:b:bap1|BAP1]]|0.44|
|[[:human genes:c:cars|CARS]]|0.436|
|[[:human genes:u:ube2k|UBE2K]]|0.43|
|[[:human genes:u:uap1|UAP1]]|0.429|
|[[:human genes:u:uhrf1|UHRF1]]|0.427|
|[[:human genes:h:hspd1|HSPD1]]|0.426|
|[[:human genes:c:crls1|CRLS1]]|0.422|
|[[:human genes:t:tmed10|TMED10]]|0.42|
|[[:human genes:a:atp5o|ATP5O]]|0.419|
|[[:human genes:c:csnk2b|CSNK2B]]|0.417|
|[[:human genes:z:znf608|ZNF608]]|0.416|
|[[:human genes:t:telo2|TELO2]]|0.415|
|[[:human genes:t:taz|TAZ]]|0.411|
|[[:human genes:r:rbm14|RBM14]]|0.41|
|[[:human genes:f:fli1|FLI1]]|0.41|
|[[:human genes:p:polr3c|POLR3C]]|0.41|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.41|
|[[:human genes:p:plaa|PLAA]]|0.41|
|[[:human genes:t:trnt1|TRNT1]]|0.41|
|[[:human genes:d:derl2|DERL2]]|0.409|
|[[:human genes:y:yars|YARS]]|0.409|
|[[:human genes:a:alg14|ALG14]]|0.409|
|[[:human genes:o:osgep|OSGEP]]|0.409|
|[[:human genes:t:thoc6|THOC6]]|0.407|
|[[:human genes:n:nsd1|NSD1]]|0.407|
|[[:human genes:a:atp5j|ATP5J]]|0.404|
|[[:human genes:r:rpn1|RPN1]]|0.401|
|[[:human genes:m:med25|MED25]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 257/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|8/28|
|bone|7/26|
|breast|13/33|
|central nervous system|19/56|
|cervix|1/4|
|colorectal|7/17|
|esophagus|3/13|
|fibroblast|1/1|
|gastric|6/16|
|kidney|6/21|
|liver|7/20|
|lung|32/75|
|lymphocyte|5/16|
|ovary|10/26|
|pancreas|7/24|
|peripheral nervous system|5/16|
|plasma cell|3/15|
|prostate|1/1|
|skin|9/24|
|soft tissue|4/9|
|thyroid|0/2|
|upper aerodigestive|5/22|
|urinary tract|9/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 559
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VMP1 Expression in NALM6 Cells: 6.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>