VMP1
Gene Information
- Official Symbol: VMP1
- Official Name: vacuole membrane protein 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 81671
- UniProt: Q96GC9
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a transmembrane protein that plays a key regulatory role in the process of autophagy. The ectopic overexpression of the encoded protein in cultured cells triggers autophagy even under nutrient-rich conditions. This gene is overexpressed in pancreatitis affected acinar cells where the encoded protein mediates sequestration and degradation of potentially deleterious activated zymogen granules in a process termed, zymophagy. [provided by RefSeq, Jul 2016].
- UniProt Summary: Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Plays a role in the initial stages of the autophagic process through its interaction with BECN1 (By similarity). Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions. {ECO:0000250, ECO:0000269|PubMed:17724469}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 559
- Expression level (log2 read counts): 6.24
VMP1 Expression in NALM6 Cells: 6.24
