VPS36

Entrez Summary: N/A
UniProt Summary: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 7/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	2/56
cervix	1/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	1/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
UM0131023 0.05μM R05 exp248	-2.03
LJH685 50μM R08 exp433	-1.82

EAP30
Vps36 ESCRT-II

ESCRT II complex
protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
late endosome to vacuole transport via multivesicular body sorting pathway
late endosome to vacuole transport
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
endosome transport via multivesicular body sorting pathway
multivesicular body assembly
multivesicular body organization
multivesicular body sorting pathway
phosphatidylinositol-3-phosphate binding
establishment of protein localization to vacuole
protein localization to vacuole
endosome organization
ubiquitin binding
late endosome membrane
vacuolar transport
macroautophagy
protein C-terminus binding
endosomal transport
lysosome
autophagy
process utilizing autophagic mechanism
endosome
vesicle organization
endomembrane system organization
establishment of protein localization to organelle
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
protein localization to organelle
organelle assembly
cellular macromolecule catabolic process
intracellular protein transport
macromolecule catabolic process
organonitrogen compound catabolic process
proteolysis
protein transport