VPS37C

Entrez Summary: N/A
UniProt Summary: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. {ECO:0000269|PubMed:15509564}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ESCRT I complex
viral budding via host ESCRT complex
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
viral budding
endosome transport via multivesicular body sorting pathway
multivesicular body assembly
multivesicular body organization
multivesicular body sorting pathway
protein targeting to vacuole
virion assembly
establishment of protein localization to vacuole
intracellular transport of virus
host cell
transport of virus
calcium-dependent protein binding
protein localization to vacuole
multi-organism localization
multi-organism transport
endosome organization
late endosome membrane
vacuolar transport
protein targeting to membrane
macroautophagy
viral life cycle
endosome membrane
endosomal transport
process utilizing autophagic mechanism
autophagy
establishment of protein localization to membrane
vesicle organization
protein targeting
endomembrane system organization
establishment of protein localization to organelle
protein localization to membrane
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process