VPS45 [The Human Chemical-Genetic Interaction Map Project]

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======= VPS45 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VPS45
  * **<color #00a2e8>Official Name</color>**: vacuolar protein sorting 45 homolog
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11311|11311]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NRW7|Q9NRW7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VPS45&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VPS45|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610035|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec1 domain family, and shows a high degree of sequence similarity to mouse, rat and yeast Vps45. The exact function of this gene is not known, but its high expression in peripheral blood mononuclear cells suggests a role in trafficking proteins, including inflammatory mediators. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sec1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vesicle docking involved in exocytosis|
|vesicle docking|
|exocytic process|
|synaptic vesicle|
|organelle localization by membrane tethering|
|membrane docking|
|endosome membrane|
|blood coagulation|
|coagulation|
|hemostasis|
|cellular component|
|wound healing|
|regulation of body fluid levels|
|response to wounding|
|organelle localization|
|Golgi membrane|
|molecular function|
|exocytosis|
|Golgi apparatus|
|intracellular protein transport|
|secretion by cell|
|export from cell|
|secretion|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.14|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.09|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.01|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-1.92|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-1.84|
|[[:results:exp169|BH1 1μM R04 exp169]]|-1.79|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-1.73|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|1.71|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.75|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.99|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.02|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:ccdc53|CCDC53]]|0.506|
|[[:human genes:v:vps8|VPS8]]|0.447|
|[[:human genes:k:kiaa1033|KIAA1033]]|0.446|
|[[:human genes:a:arpc4|ARPC4]]|0.436|
|[[:human genes:a:agfg1|AGFG1]]|0.435|
|[[:human genes:k:kiaa0196|KIAA0196]]|0.433|
|[[:human genes:a:actr3|ACTR3]]|0.426|
|[[:human genes:c:ccdc22|CCDC22]]|0.423|
|[[:human genes:r:rab5c|RAB5C]]|0.421|
|[[:human genes:p:pik3c3|PIK3C3]]|0.42|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 15/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|3/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|3/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|2/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1545
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VPS45 Expression in NALM6 Cells: 5.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>