VPS45
Gene Information
- Official Symbol: VPS45
- Official Name: vacuolar protein sorting 45 homolog
- Aliases and Previous Symbols: N/A
- Entrez ID: 11311
- UniProt: Q9NRW7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec1 domain family, and shows a high degree of sequence similarity to mouse, rat and yeast Vps45. The exact function of this gene is not known, but its high expression in peripheral blood mononuclear cells suggests a role in trafficking proteins, including inflammatory mediators. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013].
- UniProt Summary: May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 1545
- Expression level (log2 read counts): 5.49
VPS45 Expression in NALM6 Cells: 5.49
