VPS52 [The Human Chemical-Genetic Interaction Map Project]

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======= VPS52 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VPS52
  * **<color #00a2e8>Official Name</color>**: VPS52 subunit of GARP complex
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6293|6293]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N1B4|Q8N1B4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VPS52&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VPS52|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603443|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sec3|
|Vps52|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|embryonic ectodermal digestive tract development|
|ectodermal digestive tract development|
|GARP complex|
|EARP complex|
|ectodermal cell differentiation|
|Golgi to vacuole transport|
|ectoderm development|
|embryonic digestive tract development|
|endocytic recycling|
|syntaxin binding|
|retrograde transport, endosome to Golgi|
|trans-Golgi network membrane|
|post-Golgi vesicle-mediated transport|
|lysosomal transport|
|recycling endosome|
|digestive tract development|
|vacuolar transport|
|digestive system development|
|cytosolic transport|
|Rab GTPase binding|
|endosome membrane|
|endosomal transport|
|Golgi vesicle transport|
|embryonic organ development|
|tissue morphogenesis|
|perinuclear region of cytoplasm|
|tube development|
|embryo development|
|Golgi apparatus|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|tissue development|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp539|42°C R08 exp539]]|-3.3|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.45|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-2.45|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-2.22|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|-2.1|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-2.09|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.07|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-2.06|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.06|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-2.06|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-2|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.96|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-1.93|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-1.9|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|-1.88|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.88|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-1.77|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-1.77|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|-1.77|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.74|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.73|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.72|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|1.7|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.559|
|[[:human genes:c:copb2|COPB2]]|0.491|
|[[:human genes:v:vps54|VPS54]]|0.49|
|[[:human genes:c:copa|COPA]]|0.473|
|[[:human genes:v:vps51|VPS51]]|0.469|
|[[:human genes:c:copz1|COPZ1]]|0.462|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.456|
|[[:human genes:t:tssc1|TSSC1]]|0.446|
|[[:human genes:p:pola1|POLA1]]|0.444|
|[[:human genes:t:trappc11|TRAPPC11]]|0.443|
|[[:human genes:m:med14|MED14]]|0.442|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.441|
|[[:human genes:c:copg1|COPG1]]|0.438|
|[[:human genes:s:sys1|SYS1]]|0.438|
|[[:human genes:a:atp6v0b|ATP6V0B]]|0.436|
|[[:human genes:s:slc6a17|SLC6A17]]|0.434|
|[[:human genes:c:chd4|CHD4]]|0.433|
|[[:human genes:p:polr2d|POLR2D]]|0.429|
|[[:human genes:s:strn|STRN]]|0.427|
|[[:human genes:t:trappc8|TRAPPC8]]|0.426|
|[[:human genes:y:ythdc1|YTHDC1]]|0.425|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.424|
|[[:human genes:p:prim1|PRIM1]]|0.423|
|[[:human genes:u:utp3|UTP3]]|0.421|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.421|
|[[:human genes:z:znf830|ZNF830]]|0.42|
|[[:human genes:u:upf1|UPF1]]|0.419|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.418|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.416|
|[[:human genes:a:arcn1|ARCN1]]|0.415|
|[[:human genes:s:supt6h|SUPT6H]]|0.411|
|[[:human genes:o:ogdh|OGDH]]|0.409|
|[[:human genes:p:psmb2|PSMB2]]|0.406|
|[[:human genes:s:slc4a1|SLC4A1]]|0.406|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.403|
|[[:human genes:m:myb|MYB]]|0.403|
|[[:human genes:c:ccna2|CCNA2]]|0.402|
|[[:human genes:d:ddtl|DDTL]]|0.401|
|[[:human genes:s:slc38a7|SLC38A7]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 85
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VPS52 Expression in NALM6 Cells: 5.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>