VPS52
Gene Information
- Official Symbol: VPS52
- Official Name: VPS52 subunit of GARP complex
- Aliases and Previous Symbols: N/A
- Entrez ID: 6293
- UniProt: Q8N1B4
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Sec3 |
| Vps52 |
GO Terms
| embryonic ectodermal digestive tract development |
| ectodermal digestive tract development |
| GARP complex |
| EARP complex |
| ectodermal cell differentiation |
| Golgi to vacuole transport |
| ectoderm development |
| embryonic digestive tract development |
| endocytic recycling |
| syntaxin binding |
| retrograde transport, endosome to Golgi |
| trans-Golgi network membrane |
| post-Golgi vesicle-mediated transport |
| lysosomal transport |
| recycling endosome |
| digestive tract development |
| vacuolar transport |
| digestive system development |
| cytosolic transport |
| Rab GTPase binding |
| endosome membrane |
| endosomal transport |
| Golgi vesicle transport |
| embryonic organ development |
| tissue morphogenesis |
| perinuclear region of cytoplasm |
| tube development |
| embryo development |
| Golgi apparatus |
| protein transport |
| intracellular transport |
| peptide transport |
| amide transport |
| establishment of protein localization |
| tissue development |
| establishment of localization in cell |
| nitrogen compound transport |
| vesicle-mediated transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| POLR2J3 | 0.559 |
| COPB2 | 0.491 |
| VPS54 | 0.49 |
| COPA | 0.473 |
| VPS51 | 0.469 |
| COPZ1 | 0.462 |
| ATP6V1A | 0.456 |
| TSSC1 | 0.446 |
| POLA1 | 0.444 |
| TRAPPC11 | 0.443 |
| MED14 | 0.442 |
| TBC1D3H | 0.441 |
| COPG1 | 0.438 |
| SYS1 | 0.438 |
| ATP6V0B | 0.436 |
| SLC6A17 | 0.434 |
| CHD4 | 0.433 |
| POLR2D | 0.429 |
| STRN | 0.427 |
| TRAPPC8 | 0.426 |
| YTHDC1 | 0.425 |
| TBC1D3F | 0.424 |
| PRIM1 | 0.423 |
| UTP3 | 0.421 |
| TCEB3CL2 | 0.421 |
| ZNF830 | 0.42 |
| UPF1 | 0.419 |
| TBC1D3G | 0.418 |
| ATP6V0C | 0.416 |
| ARCN1 | 0.415 |
| SUPT6H | 0.411 |
| OGDH | 0.409 |
| PSMB2 | 0.406 |
| SLC4A1 | 0.406 |
| TCEB3CL | 0.403 |
| MYB | 0.403 |
| CCNA2 | 0.402 |
| DDTL | 0.401 |
| SLC38A7 | 0.401 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 6/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 1/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 1/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 2/75 |
| lymphocyte | 0/16 |
| ovary | 1/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 1/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 85
- Expression level (log2 read counts): 5.99
Expression Distribution
VPS52 Expression in NALM6 Cells: 5.99
