VRK2

Entrez Summary: This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. The encoded protein acts as an effector of signaling pathways that regulate apoptosis and tumor cell growth. Variants in this gene have been associated with schizophrenia. Alternative splicing results in multiple transcript variants that differ in their subcellular localization and biological activity. [provided by RefSeq, Jan 2014].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	-2.14
Calcipotriol 5μM R08 exp464	-1.8

Pkinase
Pkinase Tyr

regulation of interleukin-1-mediated signaling pathway
peptidyl-threonine phosphorylation
peptidyl-threonine modification
mitochondrial membrane
regulation of cytokine-mediated signaling pathway
peptidyl-serine phosphorylation
regulation of response to cytokine stimulus
protein autophosphorylation
peptidyl-serine modification
cellular response to oxidative stress
protein domain specific binding
protein serine/threonine kinase activity
response to oxidative stress
protein kinase binding
protein-containing complex
viral process
regulation of MAPK cascade
symbiotic process
interspecies interaction between organisms
peptidyl-amino acid modification
endoplasmic reticulum membrane
protein phosphorylation
endoplasmic reticulum
phosphorylation
regulation of protein phosphorylation
ATP binding
regulation of phosphorylation
cellular response to stress
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of intracellular signal transduction
regulation of protein modification process