VRK3

Gene Information

Official Symbol: VRK3
Official Name: VRK serine/threonine kinase 3
Aliases and Previous Symbols: N/A
Entrez ID: 51231
UniProt: Q8IV63
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus. {ECO:0000250, ECO:0000269|PubMed:14645249, ECO:0000269|PubMed:19141289}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13067
Expression level (log2 read counts): 5.26

Expression Distribution

Pkinase Tyr
Pkinase

positive regulation of phosphoprotein phosphatase activity
positive regulation of phosphatase activity
positive regulation of protein dephosphorylation
positive regulation of dephosphorylation
negative regulation of ERK1 and ERK2 cascade
peptidyl-threonine phosphorylation
protein phosphatase binding
peptidyl-threonine modification
regulation of phosphoprotein phosphatase activity
regulation of protein dephosphorylation
negative regulation of MAPK cascade
peptidyl-serine phosphorylation
regulation of phosphatase activity
peptidyl-serine modification
regulation of dephosphorylation
regulation of ERK1 and ERK2 cascade
protein serine/threonine kinase activity
negative regulation of protein phosphorylation
negative regulation of phosphorylation
negative regulation of intracellular signal transduction
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
intracellular membrane-bounded organelle
regulation of MAPK cascade
positive regulation of hydrolase activity
nucleolus
peptidyl-amino acid modification
protein phosphorylation
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
positive regulation of phosphate metabolic process
positive regulation of phosphorus metabolic process
positive regulation of protein modification process
negative regulation of signal transduction
regulation of hydrolase activity
phosphorylation
negative regulation of cell communication
negative regulation of signaling
positive regulation of catalytic activity