VSIG4 [The Human Chemical-Genetic Interaction Map Project]

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======= VSIG4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VSIG4
  * **<color #00a2e8>Official Name</color>**: V-set and immunoglobulin domain containing 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11326|11326]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y279|Q9Y279]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VSIG4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VSIG4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300353|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases. {ECO:0000269|PubMed:17016562, ECO:0000269|PubMed:17051150}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ig|
|V-set|
|I-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of complement activation, alternative pathway|
|negative regulation of complement activation, alternative pathway|
|complement component C3b binding|
|negative regulation of complement activation|
|negative regulation of humoral immune response|
|complement activation, alternative pathway|
|negative regulation of macrophage activation|
|negative regulation of interleukin-2 production|
|regulation of macrophage activation|
|regulation of interleukin-2 production|
|negative regulation of innate immune response|
|negative regulation of T cell proliferation|
|negative regulation of lymphocyte proliferation|
|negative regulation of mononuclear cell proliferation|
|negative regulation of leukocyte proliferation|
|negative regulation of response to biotic stimulus|
|negative regulation of T cell activation|
|regulation of complement activation|
|negative regulation of immune effector process|
|negative regulation of leukocyte cell-cell adhesion|
|regulation of humoral immune response|
|negative regulation of lymphocyte activation|
|negative regulation of immune response|
|regulation of T cell proliferation|
|negative regulation of leukocyte activation|
|negative regulation of cell-cell adhesion|
|complement activation|
|negative regulation of cell activation|
|negative regulation of defense response|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|negative regulation of multi-organism process|
|regulation of leukocyte proliferation|
|negative regulation of cell adhesion|
|negative regulation of cytokine production|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|humoral immune response|
|negative regulation of response to external stimulus|
|regulation of cell-cell adhesion|
|negative regulation of immune system process|
|regulation of innate immune response|
|regulation of immune effector process|
|regulation of lymphocyte activation|
|regulation of response to biotic stimulus|
|protein-containing complex|
|regulation of leukocyte activation|
|activation of immune response|
|regulation of cell activation|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|regulation of cytokine production|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|positive regulation of immune response|
|defense response to other organism|
|immune effector process|
|regulation of response to external stimulus|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|regulation of response to stress|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|regulation of immune system process|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16970
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VSIG4 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>